We identified that the chemical linkage of the anticancer drug doxorubicin onto squalene, a natural lipid precursor of the cholesterol's biosynthesis, led to the formation of squalenoyl doxorubicin (SQ-Dox) nanoassemblies of 130-nm mean diameter, with an original "loop-train" structure. This unique nanomedicine demonstrates: (i) high drug payload, (ii) decreased toxicity of the coupled anticanc...

Polychlorinated biphenyls (PCBs) exert a broad range of toxicity via both parent compounds and their metabolites. Our previous study showed that hydroquinone (H2Q) metabolites of PCBs act as cosubstrates for prostaglandin H synthase (PGHS), and are oxidized by this enzyme to corresponding quinones (Q). The goal of this thesis is to illuminate the PGHS-mediated toxicity of lower chlorinated PCBs...

In order to increase the accuracy of diagnosis in lung cancer, analysis concerning cytological and histological correlation was attempted. The present study consists of 106 patients, who were seen during the past approximately five years and underwent radical surgery to remove tumors completely; mere biopsy specimens were excluded. These patients were 63 years old on the average, 78 males and 2...

Reactive oxygen species induce formation of 15-F(2t)-isoprostane (15-F(2t)-IsoP), a specific marker of in vivo lipid peroxidation, which is increased after myocardial ischemia and during the subsequent reperfusion. 15-F(2t)-IsoP possesses potent bioactivity under pathophysiological conditions. However, it remains unknown whether 15-F(2t)-IsoP, by itself, can influence myocardial ischemia-reperf...

DANIELA ANCA PUSCASIU1#, GABRIELA TANASIE2#, MARIUS GEORGESCU2#, ROMULUS FABIAN TATU3*, CARMEN SOFICA TATU2 1Victor Babes University of Medicine and Pharmacy Timisoara, Microscopic Morphology Department, Cellular and Molecular Biology Discipline, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2Victor Babes University of Medicine and Pharmacy Timisoara, Functional Sciences Department, Physiolog...

Let sq denote the q-ary sum-of-digits function and let P1(X), P2(X) ∈ Z[X] with P1(N), P2(N) ⊂ N be polynomials of degree h, l ≥ 1, h 6= l, respectively. In this note we show that (sq(P1(n))/sq(P2(n)))n≥1 is dense in R. This extends work by Stolarsky (1978) and Hare, Laishram and Stoll (2011).