SMITH, GERARD P., AND ALAN N. EPSTEIN. Increased feeding in response to decreased glucose utili<ation ilz the rat and monkey. Am. J Physiol. 217(4) : 1083-1087. 1969.-The glucostatic hypothesis for the control of food intake predicts that decreased glucose utilization leads to increased food intake. Since the glucose analogue, 2-deoxy-D-glucose (Z-DG), produces decreased intracellular glucose u...

We have used mitochondrial entrapment of 2-deoxy-d-[3H]glucose (2-DG) to demonstrate that recovery of Langendorff-perfused rat hearts from ischemia is accompanied by reversal of the mitochondrial permeability transition (MPT). In hearts loaded with 2-DG before 40 min of ischemia and 25 min of reperfusion, 2-DG entrapment [expressed as 105 × (mitochondrial 2-[3H]DG dpm per unit citrate synthase)...

Dystroglycan (DG) is a cell surface glycoprotein that connects extracellular matrix molecules to the intracellular cytoskeleton, functioning as mechanical and signaling axes in various physiological events. Since the ligand-binding activity of DG strictly depends on O-mannosyl glycans attached to its extracellular α-DG subunit, aberrant glycosylation causes dystroglycanopathy, a subclass of con...

Alterations in the basement membrane receptor dystroglycan (DG) are evident in muscular dystrophies and carcinoma cells and characterized by a selective loss or modification of the extracellular alpha-DG subunit. Defects in posttranslational modifications of DG have been identified in some muscular dystrophies, but the underlying modifications in carcinoma cells have not yet been defined. We re...

Distributed Generation (DG) units are increasingly installed in the power systems. Distribution Companies (DisCo) can opt to purchase the electricity from DG in an energy purchase contract to supply the customer demand and reduce energy loss. This paper proposes a framework for optimal contract pricing of independent dispatchable DG units considering competition among them. While DG units tend ...

Effects of peripheral administration of 5-HT (5-hydroxytryptamine, serotonin) on hyperphagia induced by 2-deoxy-D-glucose(2-DG) were studied in rats. It was found that 5-HT i.p. reduced 2-DG-elicited feeding in rats dose-dependently. The 5-HT-induced hypophagia was antagonized by the 5-HT2A receptor antagonist, ketanserin. It is known that 2-DG induces glucoprivation, resulting in hyperphagia a...

In this paper, at first the appearance background electricity grid in the rural areas of west China, and its meaning as well as the concept and structure of DG technologies are resented, and a DG technologies mode of development in the rural areas of west China is given. The development ideas and the future development direction of DG in are compared and summarized. At last, the significance of...

In tumor cells growing under hypoxia, inhibiting glycolysis with 2-deoxy-d-glucose (2-DG) leads to cell death, whereas under normoxic conditions cells similarly treated survive. Surprisingly, here we find that 2-DG is toxic in select tumor cell lines growing under normal oxygen tension. In contrast, a more potent glycolytic inhibitor, 2-fluorodeoxy-d-glucose, shows little or no toxicity in thes...

Memory-related activity in the Dentate Gyrus (DG) is characterized by sparsity. Memory representations are seen as activated neuronal populations of granule cells, the main encoding cells in DG, which are estimated to engage 2-4% of the total population. This sparsity is assumed to enhance the ability of DG to perform pattern separation, one of the most valuable contributions of DG during memor...