We evaluated the regional pharmacokinetics of doxorubicin after hepatic arterial infusion (HAI) and portal venous infusion (PVI) using a novel system for hepatic venous isolation and charcoal hemoperfusion (HVI-CHP). The HVI-CHP system was used to determine directly the doxorubicin plasma concentration in the hepatic vein and the hepatic venous flow rate, and simultaneously, to eliminate hepati...

Cepharanthine (CEP), a biscoclaurine (bisbenzylisoquinoline) alkaloid isolated from Stephania cepharantha Hayata, is widely used in Japan to treat variety of diseases. Among a plethora of its biological activities CEP was reported to be able to scavenge radicals and prevent lipid peroxidation. We have recently described the phenomenon of constitutive ATM activation (CAA) and histone H2AX phosph...

Micro cogeneration – the simultaneous production of heat and power in an individual building based on small energy conversion units such as Stirling and reciprocating engines or fuel cells – is expected to increase energy efficiency on the level of household energy supply. A large-scale introduction of micro CHP may radically change the electricity system and turn consumers into power producers...

In Sweden, district heating (DH) is quite well developed and is already mainly based on non-fossil fuels. Increased use of DH is therefore considered as a way of phasing out fossil energy for heating purposes. Furthermore, increased use of DH provides an increased basis for combined heat and power production (CHP). Considering that coal condensing is the marginal production of electricity in Eu...

With the mass introduction of wind power in Northern China, wind power variability has appeared. In this article, both existing electric heat pumps (EHPs) and coal-fired combined heat and power (CHP) facilities, which are generally equipped with extraction-condensing steam turbines coupled with district heating for space heating purposes, are proposed to incorporate the variability of wind powe...

Combined heat and power (CHP) production is an increasingly important power production technology for efficient utilization of primary energy resources and for reducing CO2 emissions. In CHP plants, generation of heat and power follows joint characteristics, which means that production planning must be done in coordination. A CHP system may also comprise separate heat and power components to ma...

Environmental pressures have resulted in an increased importance being placed on the efficient production and consumption of energy. Micro combined heat and power ( CHP) technology has the potential to make an important contribution to make the transition to more sustainable energy systems since it is a highly efficient technology for generating both electricity and heat from a single fuel sour...

Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that "idiopathic" NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying cause r...

Wind power has achieved great development in Northern China, but abundant wind power is dissipated, rather than utilized, due to inflexible electricity production of combined heat and power (CHP) units. In this paper, an integrated CHP system consisting of CHP units, wind power plants, and condensing power plants is investigated to decouple the power and heat production on both the power supply...

The virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate expression of many virulence factors, including type IV pili, which are required for colonization of host tissues and for twitching motility. Type IV pilus function is controlled in part by the Chp chemosensory system, which includes a histidine kinase, ChpA, and two CheY-like response regulators, PilG an...