We developed a screening method for orphan receptor ligands, in which cell-surface proteins are expressed in Drosophila embryos from GAL4-dependent insertion lines and ligand candidates identified by the presence of ectopic staining with receptor fusion proteins. Stranded at second (Sas) binds to the receptor tyrosine phosphatase Ptp10D in embryos and in vitro. Sas and Ptp10D can interact in tr...

In the SAS DATA step, you can manipulate data by instructing SAS what to do. However, SAS understands only instructions given in its own tongue. The DATA step language (SAS DSL) is simple and powerful, its syntax is crisp and highly readable, and it is easy to learn. In this presentation, we will try to introduce the basics of speaking SAS. Just like in any language, a valid SAS phrase contain...

Subjective assessments (SAs) are assigned by users against items, such as ’elegant’ and ’gorgeous’, and are common in reviews/tags in many online-sites. However, previous studies fail to effectively use SAs for improving recommendations because few users rate the same items with the same SAs, which triggers the sparsity problem in collaborative filtering. We propose a novel algorithm that links...

In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP-orthologues of ZYG-1, SAS-6, and SAS-4, respectively-are required for centriole duplication. Strikingly, all three fly prot...

Given the growing acceptance of the Internet and Intranet as enterprise application mediums and the need for client-server computing using open solutions, SAS Institute has recognized the need to leverage existing SAS/AF® functionality to Java clients. This paper attempts to explain how technologies developed by SAS Institute allow clients written in Java to exploit the data and compute power o...

Input/Output (I/O) throughput is typically the most important computing aspect of a SAS® environment. Bandwidth requirements ranging from 25MB/sec/core to 135MB/sec/core are common in a high-performance SAS system. Insuring that the storage subsystem can meet the demands of SAS is critical to delivering the performance required by the business and user community. Ideally, SAS administrators cou...

Data sets with cluster structure are very common in practical business and research, one has to take into account the intra-cluster correlation in data analysis. This paper systematically discusses the Huber/White standard error estimate for cluster sampling data in logistic regression, and presents a user-friendly SAS/IML macro procedure which can automatically fit logistic model, calculate ro...