objective(s):reduction of pharmacological effectiveness or tolerance appears following repeated administration of many analgesic drugs. we investigated tolerance to anti-nociceptive effects of orexin-a, an endogenous potent analgesic peptide using the hot-plate test.materials and methods:orexin-a was microinjected icv (intracerebroventricular) with an interval of 12 hr for 7 continuous days and...

introduction natural and artificial radionuclides are the main sources of human radiation exposure. these radionuclides, which are present in the environment, can be dissolved into water. evidence suggests that radionuclides being entered the human body through drinking or hot spring water can be harmful for human health. materials and methods in this study,10 samples were collected from ground...

Hot flashes are experienced by over 70% of menopausal women. Criteria to classify hot flashes from physiologic signals show variable performance. The primary aim was to compare conventional criteria to Support Vector Machines (SVMs), an advanced machine learning method, to classify hot flashes from sternal skin conductance. Thirty women with > or =4 hot flashes/day underwent laboratory hot flas...

We use new and archival Chandra data to investigate the X-ray emission from a large sample of compact hot spots of FR II radio galaxies and quasars from the 3C catalog. We find that only the most luminous hot spots tend to be in good agreement with the predictions of a synchrotron self-Compton model with equipartition magnetic fields. At low hot spot luminosities inverse Compton predictions are...

Hot electrons generated through plasmonic excitations in metal nanostructures show great promise for efficiently driving chemical reactions with light. However, the lifetime, yield, and mechanism of action of plasmon-generated hot electrons involved in a given photocatalytic process are not well understood. Here, we develop ultrafast surface-enhanced Raman scattering (SERS) as a direct probe of...

-1. The effect of ambient temperature on frequency, intensity and duration of hot flashes was studied in six women with hot flashes who were exposed to cool (T a = 19°C) and warm (ira = 31°C) /'as for 8-h periods. Heart rate, skin resistance, core and skin temperatures, subjective hot flash intensity and duration were recorded. 2. In the cool T~ as compared with the warm Ta, hot flashes were si...

AIMS In breast cancer survivors, we aimed to describe the frequency of hot flashes and night sweats, frequency and type of treatment, and the association of hot flashes and use of calcium supplements. METHODS Charts of breast cancer survivors were reviewed for information about hot flashes, treatment for hot flashes, and calcium supplementation. Associations between variables were explored us...

Solid dispersion is molecular dispersion of drug in a polymer matrix which leads to improved solubility and hence better bioavailability. Solvent evaporation technique was employed to prepare films of different combinations of polymers, plasticizer, and a modal drug sulindac to narrow down on a few polymer-plasticizer-sulindac combinations. The sulindac-polymer-plasticizer combination that was ...

The aim of this study is to examine the relationship between mental workload and occurrence of hot flashes. Twelve women with moderate to severe menopausal hot flashes participated in the study. Subjects participated in both a mental arithmetic task (Task) and control (Non-task) experiments. We measured heart rate, heart rate variability, blood pressure, near infrared spectroscopy, skin tempera...