INTRODUCTION ...... . CHEMISTRy ...... . 199 200 RELATIONSHIPS BETWEEN CHEMICAL STRUCTURE AND ANTIBACTERIAL ACTIVITY.. 202 MECHANISM OF ANTIBACTERIAL ACTION. . . . . . . . 205 Activity 0/1 whole cells. . . . . . . . . .. . . . . . . . . . . 205 Activity Oil DNA-depelldellf RNA polymerase. 205 MUTATION TO RIFAMPICIN RESISTANCE. . . . . . 206 EFFECTS ON PHAGES AND PLASMlDS. . . . . . 208 STUDIES ...

Beefmaster, Brahman, Brangus, and Santa Gertrudis field data records were used to determine genetic and environmental parameter estimates using a multiple-trait, pseudo-expectation approach. Adjusted birth weight, 205-d weight, and postweaning gain records were analyzed for each breed. Also, Brangus weaning sheath and navel scores were both analyzed using a single-trait, pseudo-expectation meth...

The solution structure of the C-terminal fragment 205-316 of thermolysin has been determined by 1H-NMR methods. The fragment forms a dimer in which each subunit has two different regions: the largely disordered N-terminal segment 205-260 and the structurally well-defined segment 261-316. The structured part of each subunit is composed of three helices and is largely coincident with the correspo...

It has been shown that flavonoids have anti-tumor activity. In this study, LZ-205, a newly synthesized flavonoid, was found to be effective in inducing apoptosis in human lung cancer cells in vivo and in vitro. Mechanistically, LZ-205 triggers reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress and unfolded protein response, which could be reversed by silencing CHOP, a media...

MicroRNAs (miRNAs) are short non-coding RNA regulators that control gene expression mainly through post-transcriptional silencing. We previously identified miR-205 in a signature for human cervical cancer using a deep sequencing approach. In this study, we confirmed that miR-205 expression was frequently higher in human cervical cancer than their matched normal tissue samples. Functionally, we ...

Myeloid/lymphoid or mixed-lineage AF4 acute lymphoblastic leukemia (MLL-AF4 ALL) is a pediatric leukemia that occurs rarely in adults. MLL-AF4 ALL is typically characterized by the presence of chromosomal translocation (t(4;1l)(q21;q23)), leading to expression of MLL-AF4 fusion protein. Although MLL-AF4 fusion protein triggers a molecular pathogenesis and hematological presentations that are un...

OBJECTIVE MicroRNA-205 (miRNA-205) was revealed as an attractive prognostic tumour biomarker in recent studies. However, the results of different studies have been inconsistent. We conducted a meta-analysis to elucidate the precise predictive value of miRNA-205 in various human malignant neoplasms. DESIGN Meta-analysis. DATA SOURCES Qualified studies were identified up to 5 June 2014 by per...

Dendritic-cell (DC) targeted antigen delivery systems hold promise for enhancing vaccine efficacy and delivery of therapeutics. However, it is not known how the number and density of targeting ligands on such systems may affect DC function and subsequent T cell response. We modified the surface of biodegradable nanoparticles loaded with antigen with different densities of the mAb to the DC lect...