نتایج جستجو برای: واسنجی tdr
تعداد نتایج: 3580 فیلتر نتایج به سال:
This paper describes the design of an experimental multi-level slow intelligence system for health care, called the TDR system, consisting of interacting super-components each with different computation cycles specified by an abstract machine model. The TDR system has three major super-components: Tian (Heaven), Di (Earth) and Ren (Human), which are the essential ingredients of a human-centric ...
OBJECTIVE In our previous in vitro study mid-myocardial relative to epicardial pacing decreased transmural dispersion of depolarization (TDR) and prevented ventricular arrhythmia. We therefore hypothesized that in vivo mid-myocardial pacing in canines has a similar effect. METHODS AND RESULTS Using custom-made electrodes, monophasic action potentials were simultaneously recorded in vivo from ...
The complexity of sustainable development and societal transitions require both analytical understandings of how coupled human-environment systems function and transdisciplinary science-to-practice approaches. The academic discourse has advanced in developing a framework for defining success in transdisciplinary research (TDR). Further empirical evidence is needed to validate the proposed conce...
The emergence and spread of transmitted drug resistance (TDR) poses a major threat to the success of the rapidly expanding antiretroviral treatment (ART) programs in resource-limited countries. The World Health Organization recommends the use of the HIV Drug Resistance Threshold Survey (HIVDR-TS) as an affordable means to monitor the presence of TDR in these settings. We report our experiences ...
Antzelevitch C. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol 293: H2024–H2038, 2007. First published June 22, 2007; doi:10.1152/ajpheart.00355.2007.— This review examines the role of spatial electrical heterogeneity within the ventricular myocardium on the function of the heart in health and disease. The c...
The presence of transmitted human immunodeficiency virus (HIV)-1 drug-resistance (TDR) at the time of antiretroviral therapy initiation is associated with failure to achieve viral load (VL) suppression. Here, we report TDR surveillance in a specific population of men who have sex with men (MSM) in Belo Horizonte, Brazil. In this study, the rate of TDR was evaluated in 64 HIV-infected individual...
INTRODUCTION As availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug-resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real-time monitoring of transmitted drug resistance (TDR). SEARCH 010/RV 254 study is a prospective, longitudinal study of AHI. This analysis was performed to characterize change...
It is known that the Herpes simplex virus type 1 (HSV-1)-encoded thymidine kinase (TK) co-purifies with an associated thymidylate kinase (TMPK) activity and that thymidylate (TMP) inhibits the phosphorylation of thymidine by the HSV-1 TK. Here we demonstrate that: (i) TMP phosphorylation catalysed by the viral TMPK is competitively inhibited by thymidine (TdR) with a Ki equal to its Km as subst...
OBJECTIVES To perform a large-scale investigation of Pseudomonas aeruginosa strains with and without drug resistance in Japan. METHODS We distributed questionnaires to assess isolation rates of P. aeruginosa with and without drug resistance at medical facilities and clinical laboratories throughout Japan during the period January 2003 through June 2006. Completed questionnaires were obtained ...
BACKGROUND Frequent methamphetamine use among recently HIV infected individuals is associated with transmitted drug resistance (TDR) to non-nucleoside reverse transcriptase inhibitors (NNRTI); however, the reversion time of TDR to drug susceptible HIV may exceed 3 years. We assessed whether recreational substance use is associated with detectable TDR among individuals newly diagnosed with HIV i...
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