BoostAeroSpace AirDesign, standard of PLM collaboration in the Aerospace Industry 10h45-11h15 Coffee break 11h15-11h45 Academic keynote: Technological uncertainty, pyschological safety and knowledge maturation: the case of New Product Development 11h45-12h15 Industrial Keynote: Philippe Berthouloux and Sébastien Blanchard, STX Europe, France PLM implementation for a shipbuilding industry 12h15-...

Product Lifecycle Management (PLM) has been identified as a key concept within manufacturing industries for improving product quality, time-tomarket and costs. Previous works on this field are focused on processes, functions and information models, and those aimed at putting more intelligence on products are related to specific parts of the product lifecycle (e.g. supply chain management, shop ...

Presently, the automotive industry is facing enormous pressure due to global competition and ever changing legislative, economic and customer demands. Product and process development in the automotive manufacturing industry is a challenging task for many reasons. Current product life cycle management (PLM) systems tend to be product-focussed. Though, information about processes and resources ar...

BACKGROUND AND PURPOSE Periodic limb movements (PLM) during sleep (PLMS) are associated with cortical and cardiovascular activation. Changes in cerebral hemodynamics caused by cortical activity can be measured using near-infrared spectroscopy (NIRS). We investigated oscillatory components of cerebral hemodynamics during PLM and different sleep stages in restless legs syndrome (RLS) patients wit...

BAE Systems Naval Ships has undertaken a comprehensive overhaul of all aspects of its approach to the engineering, design and manufacture of complex warships. Through a partnership with the University of Strathclyde, research has been completed on the implementation of Product Lifecycle Management (PLM) to meet organisational objectives in the development of Engineer to Order (ETO) products. En...

Plasmepsin IV (Plm IV) is one of the aspartic proteases present in the food vacuole of the malaria parasite Plasmodium falciparum involved in host hemoglobin degradation by the parasite. Using a series of previously synthesized plasmepsin inhibitors [Ersmark, K., et al. (2005) J. Med. Chem. 48, 6090-106], we report here experimental data and theoretical analysis of their inhibitory activity tow...

Today, in order to confront the growing complexity of products and organisations, Aeronautic, Space and Defence (ASD) manufacturing enterprises are using more and more System Engineering, Product Lifecycle Management and Computer Aided Solutions for various engineering and management activities. Combined with a more and more important outsourcing, such trends led to the emergence of what is cal...

Numerous studies have suggested a substantial genetic contribution in the etiology of the primary form of restless legs syndrome (RLS) and periodic leg movements (PLM). We describe the symptoms, the sleep profiles and physiological parameters of two families in which several members present RLS/PLM. The proband of family 1 is a 70-year-old woman and the proband of family 2 is a 57-year-old woma...

This paper reviews the perennial problem of knowledge management / information integration in large scale, complex and knowledge intensive organisations such as automotive industries. Automotive industry is under increased pressure to produce low cost customised products using innovative agile manufacturing techniques. Presently this innovation has focused on the improved process development be...

In this dissertation we studied asymptotic properties of shrinkage estimators, and compared their performance with absolute penalty estimators (APE) in linear and partially linear models (PLM). A robust shrinkage M-estimator is proposed for PLM, and asymptotic properties are investigated, both analytically and through simulation studies. In Chapter 2, we compared the performance of shrinkage an...