We show here that the pvr2 locus in pepper, conferring recessive resistance against strains of potato virus Y (PVY), corresponds to a eukaryotic initiation factor 4E (eIF4E) gene. RFLP analysis on the PVY-susceptible and resistant pepper cultivars, using an eIF4E cDNA from tobacco as probe, revealed perfect map co-segregation between a polymorphism in the eIF4E gene and the pvr2 alleles, pvr2(1...

The Crystal Ball detector at SPEAR is used to analyze the decays JI' + YYIJ and $' + YX,X -t YY. Values are obtained for the branching ratios of $' * n/.rr'$ and JI' + yx,x + y$. No evidence is found for a 21So(ni) state in the mass range 3129+3644 MeV/c2. Analysis of the angular distributions in the cascade x decays yields spin and multipole assignments for the x(3.51) and x(3.55). R&urn;: On ...

BACKGROUND Alterations in gastrointestinal motility and hormone secretion, especially activation of the ileal brake, have been documented in malabsorption. AIM To investigate whether artificially-induced accelerated small intestinal transit activates the ileal brake mechanism. METHODS Eight healthy volunteers (four female, four male; age 21 +/- 3 years) participated in four experiments: (a)...

1. Abstract Sex differentiation is generally more labile in gonochoristic fish than it is, for example, in birds and mammals. Environmentally induced sex reversal is therefore often possible and creates genotype-phenotype mismatches that can be useful in population management. Interestingly, sex chromosomes of fish are typically not significantly decayed, i.e. all types of offspring of sex-reve...

RECENTLY, the United States Food and Drug Administration (FDA) decided for the present against approving the cannabinoid receptor antagonist Rimonabant for the treatment of obesity in the United States. This decision resulted mainly from concerns based on studies showing that the drug’s benefits would not outweigh its risks for side effects. This decision further diminished already limited hope...

The gut-derived hormone, peptide YY (PYY) reduces food intake and enhances satiety in both humans and animals. Obese individuals also have a deficiency in circulating peptide YY, although whether this is a cause or a consequence of obesity is unclear. Our aims were to determine whether peptide YY (PYY) over-expression may have therapeutic effects for the treatment of obesity by altering energy ...

Melanocortin-1 receptor (MC1R) and its ligands, alpha-melanocyte stimulating hormone (alphaMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes. Here we investigated biological effects and signaling pathways of ASIP. Melan-a non agouti (a/a) mouse melanocytes produce mainly eumelanin, but ASIP combined with phenylthiourea and ex...