Doubling time (DT) is widely used for quantification of tumor growth rate. DT is usually determined from two volume estimations with measurement time intervals comparable with or shorter than DT. Clinical data show that the frequency distribution of DT in patients is positively skewed, with some very long DT values compared with the average DT. Growth rate can also be quantified using specific ...

The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase (D-DT) recently has been described to have similar functions as MIF. However, the role of D-DT, as opposed to MIF, in tumor biology remains unknown. We hypothesized that D-DT could represent a target for therapeutic interventions in cancer. We analyzed the production of D-DT in the murine melanoma model B16F10 a...

Diphtheria toxin (DT), a bacterial protein exotoxin, inactivates mammalian cell elongation factor 2 after toxin internalization by receptor-mediated endocytosis. To isolate the DT receptor, we cotransfected DT-resistant wild-type mouse L-M cells with a cDNA library constructed from RNA of highly toxin-sensitive monkey Vero cells and with a neomycin-resistance gene. Stably transfected G418-resis...

dðRDÞ=dt 1⁄4 k81RDA k18RD A þ k31RDE k13RD E k19RD þ k91R D þ k21RT k12RD M dðRTÞ=dt 1⁄4 k52RT E k25RT E þ k92R T k29RT k21RT þ k62RTA k26RT A k2MRT E þ kM2M þ k12RD M dðRDEÞ=dt 1⁄4 k13RD E k31RDE þ k43RE D k34RDE þ k53RTE dðREÞ=dt 1⁄4 k34RDE k43RE D þ k54RTE k45RE T þ k94R E k49RE dðRT EÞ=dt 1⁄4 k45RE T k54RTE þ k25RT E k52RTE k53RTE dðRT AÞ=dt 1⁄4 k26RT A k62RTA k68RTA þ k76RA T k67RTA dðRAÞ=...

OBJECTIVES The purpose of this study was to evaluate the ability of novel Doppler indices of left ventricular (LV) systolic and diastolic function to predict survival in patients with congestive heart failure (CHF). BACKGROUND Congestive heart failure is associated with an increased risk of death or cardiac transplantation, yet techniques to predict survival are limited. METHODS Doppler-der...

A growing body of research has linked poor distress tolerance (DT) to obsessions, but not other OC symptom domains. However, limited research has been conducted with clinical samples. Further, there is a dearth of research regarding the moderating influence of DT on the contribution of stress to OC symptoms. In Study 1, we sought to test the specificity of the link between poor DT and greater o...

Translocation is a necessary and rate-limiting step for diphtheria toxin (DT) cytotoxicity. We have reconstituted DT translocation in a cell-free system using endosomes purified from lymphocytes and have demonstrated this using two different probe/cell systems, which provided identical results: 125I-DT/human CEM cells and 125I-transferrin-DT/mouse BW cells. The cell-free DT translocation proces...

this note introduces a new general conjecture correlating the dimensionality dt of an infinitelattice with n nodes to the asymptotic value of its wiener index w(n). in the limit of large nthe general asymptotic behavior w(n)≈ns is proposed, where the exponent s and dt are relatedby the conjectured formula s=2+1/dt allowing a new definition of dimensionality dw=(s-2)-1.being related to the topol...

In previous papers of this series the temperature-dependent Raman spectra of poly(dA).poly(dT) and poly(dA-dT).poly(dA-dT) were used to characterize structurally the melting and premelting transitions in DNAs containing consecutive A.T and alternating A.T/T.A base pairs. Here, we describe procedures for obtaining thermodynamic parameters from the Raman data. The method exploits base-specific an...