BACKGROUND Alternaria species is one of the most common molds associated with allergic diseases, and 80% of Alternaria species-sensitive patients produce IgE antibodies to a major protein allergen, Alt a 1. The structure and function of Alt a 1 is unknown. OBJECTIVE We sought to obtain a high-resolution structure of Alt a 1 using x-ray crystallography and to investigate structural relationshi...

PURPOSE Pazopanib is an effective treatment for advanced renal cell carcinoma and soft-tissue sarcoma. Transaminase elevations have been commonly observed in pazopanib-treated patients. We conducted pharmacogenetic analyses to explore mechanistic insight into pazopanib-induced liver injury. EXPERIMENTAL DESIGN The discovery analysis tested association between four-digit HLA alleles and alanin...

BACKGROUND AND AIM Liver injury is estimated by serum alanine aminotransferases (ALT) levels in experimental animal models. Laboratories use various techniques to measure ALT levels including assay reagents and chemistry analyzers. VetScan VS2 (VS2) is widely used in veterinary clinics and research laboratories for highly reproducible, convenient and effective testing. Alternatively, ALT liquid...

Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in about 10% of cancers overall and is particularly common in astrocytic brain tumors and specific types of sarcomas. Somatic cell hybridization analyses have previously shown that normal telomerase-negative fibroblasts and telomerase-positive immortalized cell lines contain repressors o...

(i) Tr(DiA) = 0 for any A ∈ A and any Di ∈ D (ii) [Di,Dj ] = ad(Qij) — inner derivation (Qij ∈ A) for any Di,Dj ∈ D (iii) Alt i,j,k Dk(Qij) = 0 for all i, j, k. The main example of such a situation is the Lie algebra ΨDifn(S 1) of the formal pseudodifferential operators on (S1)n (see [A]). The trace Tr in this example is the “noncommutative residue”, Tr(D) = the coefficient of the term x 1 · x ...