نتایج جستجو برای: ژن rab27a
تعداد نتایج: 16136 فیلتر نتایج به سال:
Purpose: The aims of this study were to investigate the clinical value Rab27a as a urinary biomarker, and its efficiency in prediction bladder cancer grade.Materials Methods: expression urine samples patients with cancer, cell line (T-24), tissue was estimated via quantitative reverse transcription polymerase chain reaction (qRT-PCR). level investigated according sex, age, histological grade qR...
BACKGROUND Secretory GTPases like Rab27B control vesicle exocytosis and deliver critical proinvasive growth regulators into the tumor microenvironment. The expression and role of Rab27B in breast cancer were unknown. METHODS Expression of green fluorescent protein (GFP) fused with wild-type Rab3D, Rab27A, or Rab27B, or Rab27B point mutants defective in GTP/GDP binding or geranylgeranylation, or...
Rab proteins constitute the largest family within the Ras superfamily of small GTPases (>60 in mammals) and are essential regulators of transport between intracellular organelles. Key to this activity is their targeting to specific compartments within the cell. However, although great strides have been made over the last 25 years in assigning functions to individual Rabs and identifying their d...
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine mela...
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