Roberto Giugliani and Ursula Matte Serviço de Genética Médica, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. Departmento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Instituto Nacional de Genética Médica Populacional, Porto Alegre, RS, Brazil. Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do ...

The author reviews the issue on whether Rett syndrome (RS) is a subtype of pervasive developmental disorders (PDDs). More than 200 articles of RS have been published in the last 10 years. Internal and external validities of RS have been established by several independent studies. There remains the question whether RS presents clinical features that meet the total criteria for PDDs. The availabl...

Luciele Medianeira Schifelbain, Silvia Regina Rios Vieira, Janete Salles Brauner, Deise Mota Pacheco, Alexandre Antonio Naujorks I Intensive Care Unit, Hospital de Caridade Dr. Astrogildo de Azevedo, Santa Maria, RS, Brazil. II Intensive Care Unit, Hospital de Clı́nicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil. III Intensive Care Unit, HCPA, Porto Alegre, RS, Brazil; Hospital Nossa Senho...

The ARIDFLO project takes a multi-disciplinary approach to the collection and analysis of data required to formulate appropriate environmental flow requirements for rivers in the Lake Eyre Basin. The key drivers of the ecological processes underpinning the health of these rivers are identified by modelling wholeof-ecosystem biological responses to hydrological events over a range of spatial and...

Historically, the use of animals for research has been important in the biomedical sciences and in the field of toxicology, but there are ethical obligations on the scientific community to follow the Three Rs of animal experimentation1 (i.e. Refinement, Reduction and Replacement), whenever it is feasible. There are also scientific, economic and regulatory restrictions, as well as societal conce...

Most vaccines for human use are complex biological mixtures consisting of one or more vaccine antigens and an adjuvant product to enhance the immune response. Consequently, vaccine batch release is based on extensive statutory required quality control emphasizing final lot testing. Traditionally, this area of research and testing requires large numbers of animals while levels of pain and suffer...

As stated at the 2003 Workshop on Satellite Data Applications and Information Extraction, there is a pressing need in today’s world to be able to “facilitate quick war fighting decisions that fully leverage the huge volumes of available information.” However, this can be a daunting task due to the massive amounts of data used to find intelligence about current situations and to predict future e...

1MD, PhD in Endocrinology, Full professor at Universidade Federal do Rio Grande do Sul (UFRGS)/Hospital das Clínicas de Porto Alegre and Santa Casa de Porto Alegre, RS, Brazil 2MSc, Graduate student in Health Sciences at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil 3MSc, Graduate student in Gynecology and Obstetrics (PPGGO UFRGS), Porto Alegre, RS...

As we have entered an era of high resolution earth observation, the RS data are undergoing an explosive growth. The proliferation of data also give rise to the increasing complexity of RS data, like the diversity and higher dimensionality characteristic of the data. RS data are regarded as RS ‘‘Big Data’’. Fortunately, we are witness the coming technological leapfrogging. In this paper, we give...

Soil respiration (Rs) plays a key role in the carbon balance of forest ecosystems. There is growing evidence that Rs is strongly correlated with canopy photosynthesis; however, how Rs is linked to aboveground attributes at various phenological stages, on the seasonal and diurnal scale, remains unclear. Using an automated closed dynamic chamber system, we assessed the seasonal and diurnal patter...