The past year has born witness to compelling demonstrations of the utility of peptide complexes with glucose regulated protein 94 (GRP94, also known as gp96) in cancer immunotherapy. Insights into the structural basis of peptide binding to GRP94 have been obtained and the role of the transporter for antigen presentation in defining the GRP94-bound peptide composition has been determined.

Mehr als ein Alarmsignal-Die vielfältigen Rollen des Hitzeschockproteins Gp96 in der angeborenen und erworbenen Immunität Abbreviations For peptide sequences the one-or three-letter amino acid code was used. SI units and standard abbrevations are not explained in the table.

PURPOSE Expression of heat shock proteins (HSPs) is of prognostic significance in several tumor types, whereas HSPs may also have clinical use as stimulators in tumor vaccination. HSP expression levels were determined in normal eyes and in uveal melanoma and tested whether HSPs expression was associated with prognostic parameters in the uveal melanoma. METHODS Expression of HSP27, HSP70, HSP9...

Previous studies have shown that human heat shock protein (hsp) 60 elicits a strong proinflammatory response in cells of the innate immune system with CD14, Toll-like receptor (TLR) 2, and TLR4 as mediators of signaling, but probably not of binding. In the present study, we directly demonstrate binding of hsp60 to the macrophage surface and find the binding receptor for hsp60 different from the...

{ We propose a scheme for the establishment of multimedia delivery channels in WAN environments that support the timing and reliability requirements of multimedia applications while allowing for better utilization of the network bandwidth. These virtual, end-to-end channels from sources to destination consist of multiple segments that (a) have a resource reservation scheme that is able to issue...