Catabolism of coagulation factor VIII (FVIII) is mediated by low-density lipoprotein receptor-related protein (LRP). The ligand-binding sites of LRP are formed by complement-type repeats (CR), and CR clusters II and IV bind most of LRP ligands. FVIII contains two major LRP-binding sites located in the A2 and A3 domains. This study was aimed to identify specific complement-type repeats of LRP in...

The human reduced folate carrier (hRFC) is reported to be regulated by up to seven alternatively spliced noncoding exons (A1, A2, A, B, C, D, and E). Noncoding exon and promoter usage was analyzed in RNAs from 27 childhood acute lymphoblastic leukemia (ALL) specimens by real-time PCR and/or 5' rapid amplification of cDNA ends (5' RACE) assay. By real-time PCR, total hRFC transcripts in ALL span...

BACKGROUND/PURPOSE Coxsackievirus A2 (Cox A2) was the predominant serotype in the enterovirus outbreak in Taiwan, 2008. However, detailed clinical features of Cox A2 infection have not been reported. In this study, we compared Cox A2 with enterovirus 71 (EV71) in terms of clinical manifestation and epidemiology during the 2008 enterovirus outbreak in Taiwan. METHODS A total of 280 hospitalize...

A granule-associated phospholipase A2 from rabbit polymorphonuclear leukocytes and a closely similar phospholipase A2 from rabbit serum have been purified to near homogeneity by ion-exchange and reverse-phase chromatography. The cellular (polymorphonuclear leukocyte) phospholipase A2 has been purified greater than 100,000-fold and the extracellular (serum) phospholipase A2 approximately 60,000-...

The CYP17 gene encodes the enzyme cytochrome P450c17alpha, which mediates both 17alpha-hydroxylase and 17,20-lyase activity in the steroid biosynthesis pathway. A T-->C polymorphism in the 5' promoter region of CYP17 has been described. To examine the association between recurrent pregnancy loss (RPL) and a polymorphism in CYP17, a case-control study of 117 cases with RPL and 164 controls was c...

Selim, Niazy, Gene D. Branum, Xia Liu, Richard Whalen, and Thomas D. Boyer. Differential lobular induction in rat liver of glutathione S-transferase A1/A2 by phenobarbital. Am J Physiol Gastrointest Liver Physiol 278: G542– G550, 2000.—Phenobarbital and other xenobiotics induce drug-metabolizing enzymes, including glutathione S-transferase A1/A2 (rGSTA1/A2). We examined the mechanism of inducti...

Background Heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) belongs to a heterogenous family of nuclear proteins, importantly involved in mRNA traffi cking, translational and transcriptional processes. Recent evidence let suggest that hnRNPs post-transcriptionally modulate expression of infl ammatory mediators such as cyclooxygenase-2, tumour necrosis factor α (TNFα), interleukin 1β (IL-1β...

The development of two different immunoassays for the determination fumonisin B1 in wheat samples is reported. A previously described mimopeptide (FB1) was used to produce fusion proteins combination with luciferases: Gaussia luciferase (GLuc) and NanoLuc (NLuc). production, expression based on these (A2-GLuc A2-NLuc) detailed. assay showing best performance, A2-NLuc, a limit detection 0.61 ng ...

The purpose of this article is to introduce a new subclass analytic and bi-univalent functions, in associated with sigmoid function investigate the upper bounds for |a2| |a3|, where a2, a3 are initial Taylor-Maclaurin coefficients. Further we obtain Fekete-Szego inequalities class sigma. We also give several illustrative examples functionclass which here.

Let B(n) denote the collection of all set partitions of [n]. Suppose A1,A2 ⊆ B(n) are cross-intersecting i.e. for all A1 ∈ A1 and A2 ∈ A2, we have A1 ∩A2 6= ∅. It is proved that for sufficiently large n,