نتایج جستجو برای: گیرنده cb1 win

تعداد نتایج: 17934  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شاهد - دانشکده علوم انسانی 1390

چکیده خروجی های ارکسینرژیک از هیپوتالاموس جانبی (lh) به ناحیه-ی تگمنتوم شکمی (vta) در اکتساب ترجیح مکان شرطی (cpp) ناشی از مورفین نقش بسیار مهمی را ایفا می کند. این در حالی است که اطلاعات کمی در مورد عملکرد یا اثر ارکسین بر cpp در دسترس می باشد. بعلاوه، مطالعات بیوشیمیایی، فارماکولوژی و عملکردی تعامل و برهمکنش بین گیرنده های ارکسینی (ox1) و کانابینوئیدی (cb1) را بیان کرده ا ند. گیرنده های ارک...

ارضی, اردشیر, خدایار, محمد جواد, زرین دست, محمدرضا, سرهرودی, شادی,

زمینه و هدف کانابینوئیدها که اجزای فعال ماری‌جوانا می‌باشند و اثراتی شبیه به اوپیوئیدها دارند. به‌علاوه میان این دو سیستم تداخلات عملکردی نیز وجود دارد. هدف این مطالعه بررسی اثر سیستم کانابینوئیدی بر اضطراب در آمیگدال مرکزی، و تداخل آن با سیستم اوپیوئیدی است. روش بررسی در مطالعه حاضر، اثر تزریق داخل صفاقی داروهای اوپیوئیدی بر پاسخ حاصل از تزریق داخل آمیگدال عوامل کانابینوئیدی در موش‌های صحرایی،...

Journal: :The Journal of the American Osteopathic Association 2005
Stephanie L Tang Edward J Wagner

Cannabinoids regulate biological processes governed by the hypothalamus including, but not limited to, energy homeostasis and reproduction. The present study sought to determine whether cannabinoids modulate A-type K(+) currents (I(A)) in neurons of the hypothalamic arcuate nucleus (ARC). Whole cell patch-clamp recordings were performed in slices through the ARC prepared from castrated female a...

2004
J. Stuart Snelson

THE INTELLECTUAL INVENTION THAT SURPASSES ALL OTHERS AS THE MOST BENEFICIAL ADVANCE OF HUMAN HISTORY IS RARELY UNDERSTOOD OR APPRECIATED BY EDUCATED ADULTS. With dire consequences for such neglect, there has been no applause for this wondrous invention, no gratitude for its beneficence, no monuments to hail its priceless influence. Largely overlooked, ignored, or taken for granted, this unceleb...

Journal: :International Journal of Molecular Sciences 2021

A molecular docking approach was employed to evaluate the binding affinity of six triterpenes, namely epifriedelanol, friedelin, ?-amyrin, ?-amyrin acetate, ?-amyrin and bauerenyl towards cannabinoid type 1 receptor (CB1). Molecular studies showed that epifriedelanol had strongest CB1. dynamics simulation revealed friedelin engaged in stable non-bonding interactions by a pocket close active sit...

Journal: :Molecular pharmacology 1999
Q Tao S D McAllister J Andreassi K W Nowell G A Cabral D P Hurst K Bachtel M C Ekman P H Reggio M E Abood

The human cannabinoid receptors, central cannabinoid receptor (CB1) and peripheral cannabinoid receptor (CB2), share only 44% amino acid identity overall, yet most ligands do not discriminate between receptor subtypes. Site-directed mutagenesis was employed as a means of mapping the ligand recognition site for the human CB2 cannabinoid receptor. A lysine residue in the third transmembrane domai...

2001
Jean-Luc Bueb Didier M. Lambert Eric J. Tschirhart

Cannabinoids can activate CB1 and CB2 receptors. Since a CB2 mRNA has been described in rat peritoneal mast cells (RPMC), we investigated a series of cannabinoids and derivatives for their capacity to stimulate RPMC. Effects of natural cannabinoids v9-tetrahydrocannabinol (v9-THC), v8-THC, endocannabinoids (anandamide, palmitoylethanolamide) and related compounds (N-decanoyl-, N-lauroyl-, N-myr...

Journal: :Behavioural brain research 2003
Styliani Vlachou George G Nomikos George Panagis

CB(1) cannabinoid receptor agonists show a different profile compared to other drugs of abuse on the basis of experimental data that reveal their reinforcing properties. Thus, there are controversial data in the literature concerning the ability of CB(1) receptor agonists to reinforce behavioral responses in experimental animals, i.e. to lower self-stimulation thresholds, and to support self-ad...

Journal: :The Journal of pharmacology and experimental therapeutics 2006
Sachin Patel Cecilia J Hillard

Extracts of Cannabis sativa have been used for their calming and sedative effects for centuries. Recent developments in drug discovery have suggested that modulation of neuronal endogenous cannabinoid signaling systems could represent a novel approach to the treatment of anxiety-related disorders while minimizing the adverse effects of direct acting cannabinoid receptor agonists. In this study,...

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