Cryptococcus neoformans PKH2-01 and PKH2-02 are orthologous to mammalian PDK1 kinase genes. Although orthologs of these kinases have been extensively studied in S. cerevisiae, little is known about their function in pathogenic fungi. In this study, we show that PKH2-02 but not PKH2-01 is required for C. neoformans to tolerate cell wall, oxidative, nitrosative, and antifungal drug stress. Deleti...

.......................................................................................................... 3 INTRODUCTION .................................................................................................. 4 STUDY SITE ......................................................................................................... 5 Historical Development and Land Use ......................

One-hundred five influenza B-positive specimens obtained from southeast Asia in 2002 were categorized on the basis of DNA sequencing of HA1 gene as well as real-time PCR analysis of the NA gene. Phylogenetic analysis of the HA1 gene sequences showed that the majority of the viruses (96.2%) belonged to the B/Victoria/2/87 lineage, while a smaller percentage of the viruses (3.8%) belonged to the ...

Water is an important asset for the maintenance of life and socioeconomic development. Aquatic environments have been anthropized, receiving a large polluting load, mainly from trace elements.This study investigates occurrence health risks caused by 15 elements in surface water João Leite stream. Health risk indices were evaluated as average daily dose (ADD), hazard quotient (HQ), index carcino...

30 MELHORES RESUMOS DE TRABALHOS APRESENTADOS NO EVENTO XXI JOCAPE (ONLINE) – JORNADA ODONTOLÓGICA DO CAPE. 
 Dias 01, 02 e 03 de dezembro 2021

Methods On 10/02/2015 we emailed a standard questionnaire to all attendees to gather demographic, clinical and exposure information and laboratory results. We defined cases as attendees with vomiting, nausea, abdominal pain or diarrhea between 27/01-02/02/2015. We interviewed food handlers and tested leftovers of the sandwiches served. Faecal specimens of five cases were tested for enteric path...

BACKGROUND This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China. METHODS CBZ-SJS/TEN patients and CBZ-tolerant control patients were genotyped for HLA-B*15:02 by PCR amplification using sequence-specific primers. Pati...

Plasma DBH activity was studied in a group of 50 normal individuals, a group of 53 diabetics diagno sed less than 2 years ago (01) and a group of 49 diabetics diagnosed more than 10 years ago (02). The enzyme activity was significantly different in the 2 groups, 01 having the lower activity and G2 the highest. We interpret our results accepting that in G1 the damage of noradrenergic terminals a...