Communication about the risks of medicines is not a new issue. Patients have long since sought advice about remedies, whether from family, healthcare workers or the wider community in traditional ways, or via websites and social media in today’s world. As pharmacovigilance professionals, interacting with patients, healthcare professionals, health policy makers, journalists and the general publi...

OBJECTIVES Cobicistat (COBI) enhances atazanavir (ATV) pharmacokinetic parameters similarly to ritonavir (RTV) in both healthy volunteers and HIV-infected adults. Primary efficacy and safety outcomes of this Phase 3, international, randomized, double-blind, double-dummy, active- controlled trial in HIV-1-infected treatment-naïve adults (GS-US-216-0114/NCT01108510) demonstrated that ATV+COBI was...

Amanda Daley is a senior research fellow (exercise and health psychology) at The Centre for Sport and Exercise Science (Sheffield Hallam University, Sheffield, South Yorkshire S10 2BP, UK. Tel: 0114 225 4426; e-mail: [email protected]). Her main interests are the psychological effects of exercise in non-clinical and clinical populations. There is widespread support for a positive and lasting re...

Chemical-mechanical polishing (CMP) and other manufacturing steps in very deep submicron VLSI have varying effects on device and interconnect features, depending on local characteristics of the layout. To improve manufacturability and performance predictability, we seek to make a layout uniform with respect to prescribed density criteria, by inserting “area fill” geometries into the layout. In ...

Field emission scanning electron microscopy (FESEM), two-dimensional X-ray diffraction (2DXRD), and transmission electron microscopy coupled with selected area electron diffraction (TEMSAED) analyses of the reactant/product textural relationship show that the thermal decomposition of Iceland spar single crystals according to the reaction CaCO3(s) → CaO(s) + CO2(g) is pseudomorphic and topotacti...

Additive fuzzy systems can filter impulsive noise from signals. Alpha-stable statistics model the impulsiveness as a parametrized family of probability density functions or unit-area bell curves. The bell-curve parameter ct ranges through the interval (0, 2] and gives the Gaussian bell curve when 0t = 2 and gives the Cauchy bell curve when ~t = 1. The impulsiveness grows as ~ falls and the bell...

There is an upsurge in interest in the Markov model and also more general stationary ergodic stochastic distributions in theoretical computer science community recently (e.g. see [Vitter,KrishnanSl], [Karlin,Philips,Raghavan92], [Raghavan9 for use of Markov models for on-line algorithms, e.g., cashing and prefetching). Their results used the fact that compressible sources are predictable (and v...

This paper studies how to conduct efficiency assessment using data envelopment analysis (DEA) in interval and/or fuzzy input–output environments. A new pair of interval DEA models is constructed on the basis of interval arithmetic, which differs from the existing DEA models handling interval data in that the former is a linear CCR model without the need of extra variable alternations and uses a...

Chen, L. 2017. Molecular Tools for Biomarker Detection. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1387. 48 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0114-3. The advance of biological research promotes the emerging of new methods and solutions to answer the biological questions. This thesis describes several new molecular tools and t...

Methicillin-resistant Staphylococcus aureus (MRSA) burden is increasing worldwide in hospitals [healthcare-associated (HA)-MRSA] and in communities [community-associated (CA)-MRSA]. However, the impact of CA-MRSA within hospitals remains limited, particularly in Latin America. A countrywide representative survey of S. aureus infections was performed in Argentina by analyzing 591 clinical isolat...