BACKGROUND An increasing number of studies have examined the ability of programmed death-ligand 1 (PD-L1) to function as a marker for tumor prognosis. However, whether PD-L1 expression is a prognostic factor for the poor outcomes in many human cancers remains controversial. This study aims to investigate the prognostic role of PD-L1 expression through a meta-analysis update of 60 studies. MET...

ALEXANDER W.A. KELLNER1 and RICARDO A. AZEVEDO2 1Laboratório de Sistemática e Tafonomia de Répteis Fósseis, Departamento de Geologia e Paleontologia, Museu Nacional/UFRJ, Quinta da Boa Vista, s/n, Bairro Imperial de São Cristóvão, 20940-040 Rio de Janeiro, RJ, Brasil 2Departamento de Genética, Escola Superior de Agricultura “Luiz de Queiroz”, Universidade de São Paulo, 13418-900 Piracicaba, SP,...

In recent years, research has shown the involvement of free radicals in the development of the pain that accompanies many pathological conditions. In the treatment of acute and chronic pain, the most effective therapies are natural and synthetic opioid alkaloids. Their metabolism in itself may contribute to the formation of free radicals and thus affect body system load and the perception of pa...

Abstract A 2 mm gas gap Resistive Plate Chamber with bakelite plates has been operated in avalanche mode under a 137Cs source irradiation. We report on measurements of the efficiency in cosmic rays detection and of the charge developed in the gap, performed for two different gas mixtures: the first containing a high percentage of environmental friendly ”freon” C2H2F4; the second one having a hi...

Introduction The PFAPA syndrome is a non-mendelian autoinflammatory disease of unknown aetiology characterized by Periodic Fever, Aphthous stomatitis, Pharyngitis, and cervical Adenitis. In typical cases, attacks begin before the age of five and occur every 2-8 weeks, often with striking periodicity. We have previously profiled the blood cells and serum cytokine levels in a cohort study of pati...

Increasing evidence implicates long noncoding RNAs (lncRNAs), a class of noncoding RNAs >200 nucleotides in length, in the development of cancer. However, the mechanism underlying the effects of lncRNAs in prostate cancer (PCa) remains to be elucidated. The present study aimed to investigate the role of lncRNA‑THBS4‑003 in the pathogensis of PCa. In the present study, a microarray containing 8,...

Immunotherapeutic herpes simplex virus 2 (HSV-2) vaccine efficacy depends upon the promotion of antigen-specific immune responses that inhibit reactivation or reactivated virus, thus controlling both recurrent lesions and viral shedding. In the present study, a candidate subunit vaccine, GEN-003/MM-2, was evaluated for its ability to induce a broad-spectrum immune response in mice and therapeut...

Mature weight, maturation rate and lifetime maternal performance, through a maximum of seven calving seasons, were analyzed for 182 cows of Angus (A) and Milking Shorthorn (S) breeds and the two reciprocal crossbred groups. Mature weight and rate of maturation were estimated for the three-parameter growth curve described by Brody. Estimates derived for mature weight (kilograms), both unadjusted...

1 MD, General Clinical Research Center and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa. Correspondência para: Marcelo Correia, MSc, MD, PhD, Department of Clinical Medicine. State University of Rio de Janeiro. Av. Lineu de Paula Machado, 850 – 22470-040 – Rio de Janeiro, RJ. E-mail: [email protected] Recebido: 5/5/2008 Aceito: 28/5/20...