Abrocitinib, a once-daily oral Janus kinase 1 selective inhibitor, has shown efficacy and safety in previous studies for treating moderate-to-severe atopic dermatitis (AD). Abrocitinib is primarily eliminated via the liver, but its major circulating metabolites are mainly by renal excretion. In this phase 1, nonrandomized, open-label, single-dose (200 mg) study (NCT03660241), we evaluated impac...

Human bonelPlutoniumfUraniumlSemipalatinsk nuclear test siteAnternal dose. To evaluate the present levels of 239'240Pu and U in residents living near the Semipalatinsk nuclear test site, more than 70 bone samples were obtained at autopsy. The subjects ranged in age from 30 to 86 years (mean 59.3±12.9). Most of the samples consisted of victims who died of various diseases. Plutonium and U were r...

135 Address for correspondence: Michelangelo Mancuso, Department of Experimental and Clinical Medicine, Neurological Clinic, University of Pisa, Via Roma 67, Pisa, Italy. Tel. +39 050 992440. Fax +39 050554808. E-mail: [email protected] In recent years, there has been a surge of interest in mitochondrial diseases, a group of metabolic conditions caused by impairment of the oxidative...

The new hospital for the insane is intended for a daily average number of from 050 to 700 males and 175 to 200 female patients, and will be so situated and constructed that, as is not improbable, it will be capable of considerable extension in several directions. The area of land taken up is extensive, 'lhis is important, because it is fairly certain that a modern well-managed hospital of this ...

Results: Postoperative IOP in both groups fell significantly (P=<0.05) below the preoperative medically controlled IOP. At initial 2 months postoperative IOP was almost similar in bothgroups (mean IOP in phacotrab group was 11 mm Hg vs mean IOP in ECCE trab group as 13 mm Hg i.e P= >.050). At 12 months, the IOP in phacotrab group was lower than ECCE trab group. Postoperative visual recovery was...