نتایج جستجو برای: 1 and 8

تعداد نتایج: 17297472  

2016

1KIRTHI SATHYAKUMAR, MD, 1ANURADHA CHANDRAMOHAN, MD, FRCR, 2DIPTI MASIH, MD, 3MARK RANJAN JESUDASAN, MS, 2ANNA PULIMOOD, MD and 1ANU EAPEN, DMRD, DNB Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India Department of General and Colorectal Surgery, Unit II, Christian Medical College, Vellore...

2013
Lauren A. Sugden Michael R. Tackett Yiannis A. Savva William A. Thompson Charles E. Lawrence

Motivation: Validation and reproducibility of results is a central and pressing issue in genomics. Several recent embarrassing incidents involving the irreproducibility of high-profile studies have illustrated the importance of this issue and the need for rigorous methods for the assessment of reproducibility. Results: Here, we describe an existing statistical model that is very well suited to ...

Journal: :International Astronomical Union Colloquium 1977

Journal: :Journal of experimental political science (Print) 2021

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2006
Sara W Montminy Naseema Khan Sara McGrath Mitchell J Walkowicz Fiona Sharp Joseph E Conlon Koichi Fukase Shoichi Kusumoto Charles Sweet Kensuke Miyake Shizuo Akira Robert J Cotter Jon D Goguen Egil Lien

At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)–lipid A with poor Tolllike receptor 4 (TLR4)–stimulating activity. To address the effect of weak TLR4 stimulation on virulence, we modified Y. pestis to produce a potent TLR4-stimulating LPS. Modified Y. pestis was completely avirulent after subcutaneous infection even at high challenge doses...

2006
M Germana Sanna Sheng-Kai Wang Pedro J Gonzalez-Cabrera Anthony Don David Marsolais Melanie P Matheu Sindy H Wei Ian Parker Euijung Jo Wei-Chieh Cheng Michael D Cahalan Chi-Huey Wong Hugh Rosen

Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through genetic manipulations and (ii) to investigate their potential for therapeutic modulation. Vascu...

2006
SEOK - GU KANG JONG SOO KIM KWAN PARK JONG SUNG KIM MORRIS D. GROVES DO - HYUN NAM

The purpose of this study was to determine whether a combination treatment of temozolomide with celecoxib is effective in the rat orthotopic glioma model. After stereotactic injection of C6/LacZ rat glioma cells into the Sprague Dawley rat brain, the rats were randomly assigned to four treatment groups [group 1, control treatment; group 2, celecoxib (25 mg/kg p.o. everyday) alone; group 3, temo...

2015
Danilo Elton Evangelista André Rodrigues Flávio Henrique-Silva

The cell wall in plants offers protection against invading organisms and is mainly composed of the polysaccharides pectin, cellulose, and hemicellulose, which can be degraded by plant cell wall degrading enzymes (PCWDEs). Such enzymes are often synthesized by free living microorganisms or endosymbionts that live in the gut of some animals, including certain phytophagous insects. Thus, the abili...

2015
Pia C. Svendsen Jae-Ryeon Ryu William J. Brook

The Drosophila Tbx20 homologs midline and H15 act as selector genes for ventral fate in Drosophila legs.midline and H15 expression defines the ventral domain of the leg and the two genes are necessary and sufficient for the development of ventral fate. Ventral-specific expression of midline and H15 is activated by Wingless (Wg) and repressed by Decapentaplegic (Dpp). Here we identify VLE, a 5 k...

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