نتایج جستجو برای: 1 and 8
تعداد نتایج: 17297472 فیلتر نتایج به سال:
1KIRTHI SATHYAKUMAR, MD, 1ANURADHA CHANDRAMOHAN, MD, FRCR, 2DIPTI MASIH, MD, 3MARK RANJAN JESUDASAN, MS, 2ANNA PULIMOOD, MD and 1ANU EAPEN, DMRD, DNB Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India Department of General and Colorectal Surgery, Unit II, Christian Medical College, Vellore...
Motivation: Validation and reproducibility of results is a central and pressing issue in genomics. Several recent embarrassing incidents involving the irreproducibility of high-profile studies have illustrated the importance of this issue and the need for rigorous methods for the assessment of reproducibility. Results: Here, we describe an existing statistical model that is very well suited to ...
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At mammalian body temperature, the plague bacillus Yersinia pestis synthesizes lipopolysaccharide (LPS)–lipid A with poor Tolllike receptor 4 (TLR4)–stimulating activity. To address the effect of weak TLR4 stimulation on virulence, we modified Y. pestis to produce a potent TLR4-stimulating LPS. Modified Y. pestis was completely avirulent after subcutaneous infection even at high challenge doses...
Sphingosine 1-phosphate (S1P, 1) regulates vascular barrier and lymphoid development, as well as lymphocyte egress from lymphoid organs, by activating high-affinity S1P1 receptors. We used reversible chemical probes (i) to gain mechanistic insights into S1P systems organization not accessible through genetic manipulations and (ii) to investigate their potential for therapeutic modulation. Vascu...
The purpose of this study was to determine whether a combination treatment of temozolomide with celecoxib is effective in the rat orthotopic glioma model. After stereotactic injection of C6/LacZ rat glioma cells into the Sprague Dawley rat brain, the rats were randomly assigned to four treatment groups [group 1, control treatment; group 2, celecoxib (25 mg/kg p.o. everyday) alone; group 3, temo...
The cell wall in plants offers protection against invading organisms and is mainly composed of the polysaccharides pectin, cellulose, and hemicellulose, which can be degraded by plant cell wall degrading enzymes (PCWDEs). Such enzymes are often synthesized by free living microorganisms or endosymbionts that live in the gut of some animals, including certain phytophagous insects. Thus, the abili...
The Drosophila Tbx20 homologs midline and H15 act as selector genes for ventral fate in Drosophila legs.midline and H15 expression defines the ventral domain of the leg and the two genes are necessary and sufficient for the development of ventral fate. Ventral-specific expression of midline and H15 is activated by Wingless (Wg) and repressed by Decapentaplegic (Dpp). Here we identify VLE, a 5 k...
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