OBJECTIVES beta-Blockers are standard therapy for patients with heart failure (HF). This study compared the effects of chronic monotherapy with 2 different beta(1)-selective adrenoceptor blockers, namely atenolol and metoprolol succinate, on left ventricular (LV) function and remodeling in dogs with coronary microembolization-induced HF [LV ejection fraction (EF) 30-40%]. METHODS Twenty HF do...

A phosphatidylinositol 4-kinase activator (PIK-A49) has been purified from carrot cells grown in suspension culture. The activator was purified from a soluble fraction using DEAE-Sepharose CL-6B and S-Sepharose chromatography columns. PIK-A49 has a relative molecular mass of 49 kDa determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The A50 for the activation of the Triton ...

Earlier studies have shown that translation elongation factor 1 (EF-1 ) is hyperphosphorylated in various mammalian cells infected with representative alpha-, beta-, and gammaherpesviruses and that the modification is mediated by conserved viral protein kinases encoded by herpesviruses, including UL13 of herpes simplex virus type 1 (HSV-1), UL97 of human cytomegalovirus, and BGLF4 of Epstein-Ba...

Higher plant proteins immunologically related to the animal substrate adhesion molecule vitronectin have recently been observed and implicated in a variety of biological processes, such as plasma membrane-cell wall adhesion, pollen tube extension, and bacterium-plant interaction. We provide evidence that, similar to vitronectin, one of these proteins, PVN1 (plant vitronectin-like 1), isolated f...

Executive function (EF) is an important predictor of numerous developmental outcomes, such as academic achievement and behavioral adjustment. Although a plethora of measurement instruments exists to assess executive function in children, only few of these are suitable for toddlers, and even fewer have undergone psychometric evaluation. The present study evaluates the psychometric properties and...

Introduction Despite clinical guideline recommendations to use left ventricular ejection fraction (EF) as a marker of function in heart failure (HF), it is prone measurement error, load dependent and skewed during geometric cardiac remodelling. EF also cannot distinguish between patients with HF preserved (HFpEF) those normal heart. By evaluating at the mid-wall layer (the corrected (E...

There has been much theoretical discussion of a functional link between theory of mind (ToM) and executive function (EF) in autism. This study sought to establish the relationship between ToM and EF in young children with autism (M = 5 years, 6 months) and to examine issues of developmental primacy. Thirty children with autism and 40 typically developing children, matched on age and ability, we...

CaBP1 (calcium-binding protein 1) is a 19.4-kDa protein of the EF-hand superfamily that modulates the activity of Ca(2+) channels in the brain and retina. Here we present data from NMR, microcalorimetry, and other biophysical studies that characterize Ca(2+) binding, Mg(2+) binding, and structural properties of recombinant CaBP1 purified from Escherichia coli. Mg(2+) binds constitutively to CaB...

The objective of this study is to investigate the impact exports, renewable energy, and industrialization on ecological footprint (EF) India over period spanning from 1970–2017 by employing newly developed augmented ARDL (A-ARDL) co-integration approach novel dynamic (D-ARDL) technique. empirical results demonstrate that exports energy consumption reduce EF, while intensifies EF. More precisely...

Translational elongation factor is an essential component for protein synthesis that functions by binding aminoacylated tRNAs to the ribosome-mRNA complex. This function is performed by EF-Tu in prokaryotes and eukaryotic organelles, and by EF-la in eukaryotes (for review see Miller and Weissbach, 1977). In lower photosynthetic eukaryotes, including Chlamydomonas (Baldauf and Palmer, 1990) and ...