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Immunological explanatory approaches are becoming increasingly important in schizophrenia research. In this context, the function of blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) (BCSFB) plays an essential role. Different adhesion molecules, such as intercellular molecule-1 (ICAM-1) vascular cell (VCAM-1), key elements sustaining integrity BBB BCSFB. The objectives study were to...
BACKGROUND Our objective was to evaluate and compare the effect of abacavir on levels of biomarkers associated with cardiovascular risk. METHODS In an open-label randomized trial, HIV-infected patients were randomized 1:1 to switch from zidovudine/lamivudine to abacavir/lamivudine or tenofovir/emtricitabine. In the present analysis, we measured levels of interleukin-6 (IL-6), high-sensitivity...
Lopes-Virella et al. (1) recently reported on a substudy of the Diabetes Control and Complications Trial (DCCT) and claimed that in addition to the soluble tumor necrosis factor receptors (TNFR)-1 and -2, a biomarker of endothelial dysfunction, soluble E-selectin (sE-selectin) is also a predictor for macroalbuminuria in type 1 diabetes (T1D). The data on TNFR-1 and -2 confirm previous work from...
ABSTRACT However, whether the beneficial effect of fenofibrate on the endothelium is related to reduction of ADMA level in individuals with diabetes mellitus (DM) is not known, and the current study aimed to address this issue. Aim: A total of 60 patients with type 2 DM and dyslipidemia (aged 45 ± 8 years; mean ± SD) were compared to 59 healthy controls without type 2 DM and normolipidemia (age...
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