Gerstmann-Sträussler-Scheinker Disease (GSS) is a familial neurodegenerative disorder characterized clinically by ataxia, parkinsonism, and dementia, and neuropathologically by deposition of diffuse and amyloid plaques composed of prion protein (PrP). The purpose of this study was to evaluate if [(11)C]Pittsburgh Compound B (PiB) positron emission tomography (PET) is capable of detecting PrP-am...

Abstraction based programming has been traditionally seen as an approach that improves software quality at the cost of losing performance. In this paper, we explore the cost of abstraction by transforming the PARSEC benchmark fluidanimate application from low-level, hand-optimized C to a higher-level and more general C++ version that is a more direct representation of the algorithms. We elimina...

Tricyclic ring systems, possessing the dibenzo structure joined to the central seven membered heterocyclic ring with a basic side chain, have been a rich source of biologically active molecular entities and frequently show effects on the central nervous system [10]. The precise mechanism of action of these compounds is not known [2]. Therefore to further elucidate the mechanism of action and to...

In this study, litters of rat pups and their mothers were continuously video-monitored from Day 14 to Day 35 postpartum in order to describe the behavioral changes that occur during that period. Prior to the onset of solid food intake (Day 18). pups spent most of their active time suckling. During Days 18 to 26, feeding, drinking, grooming, and play-fighting rapidly became frequent daily activi...

Parallel hardware makes concurrency mandatory for efficient program execution. However, writing concurrent software is both challenging and error-prone. C++11 provides standard facilities for multiprogramming, such as atomic operations with acquire/release semantics and RAII mutex locking, but these primitives remain too low-level. Using them both correctly and efficiently still requires expert...

We investigate the Coulomb part of the one-neutron removal cross section in breakup reactions of the neutron rich nuclei Be and C. Approximate Coulomb breakup amplitudes are derived from two distinct theoretical viewpoints. One of these uses an approximation to the distorted-wave Born approximation. The other assumes an adiabatic treatment of the projectile excitation to the low energy continuu...

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It sometimes happens that the data collected are only in rank form within each block or normality cannot be assumed in the randomized block design. In these situations, a nonparametric approach called the Friedman rank test can be utilized. The Friedman rank test is primarily used to test whether c sample groups (i.e., the treatment levels) have been selected from populations having equal media...