A novel Ti/111In-heterometallic radiotheranostic along with non-radioactive Ti/In, Ti/Lu, and Ti/Y analogues has been reported, thanks to the design of a challenging synthesis of the first titanocene-DOTA ligand. The corresponding titanocene-BODIPY complex was developed for in vitro tracking by optical imaging. The different complexes were characterized and their antiproliferative properties we...

UNLABELLED Imaging with radiolabeled somatostatin (SST) analogs has recently been established for the localization of various human SST receptor (hsstr)-positive tumors, including neuroendocrine tumors, lymphomas, and non-small cell lung cancer (NSCLC). METHODS 111In-1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-lanreotide (DOTA-LAN) scintigraphy (150 MBq; 7 nmol per patient) wa...

To study the effects of antithrombotic therapy in experimental stroke, we have characterized a baboon model of acute cerebrovascular thrombosis. In this model an inflatable silastic balloon cuff has been implanted by transorbital approach around the right middle cerebral artery (MCA), proximal to the take-off of the lenticulostriate arteries (LSA). Inflation of the balloon for 3 hours in six an...

A human B-cell lymphoma xenograft model was used to test whether the administration of unlabeled MoAb prior to injection of radiolabeled monoclonal antibody (MoAb) improves delivery of the radiolabeled MoAb to tumor prior to testing in clinical radioimmunotherapy trials. The anti-B1/CD20 pan-B-cell MoAb reactive with human B-cell lymphomas and leukemias but not reactive with mouse B-cells was u...

d-Glucosamine (DG) was conjugated to a core-cross linked polymeric micelle (CCPM) system equipped with both a near-infrared fluorophore (NIRF) and a gamma emitter (111In). The resultant nano-scale tumor-targeting imaging tracer, 111In-DG-NIRF-CCPM, selectively accumulated in a human epithelial carcinoma A-431 xenograft model in mice. At 24 hrs post injection, the tumor uptake was 2.62 ± 0.80 % ...

Platelet dynamics in chronic liver disease have been studied using 111Indium-8-hydroxyquinolone (111In-oxine) as a platelet label. In 20 patients, mainly with alcoholic cirrhosis, the platelet mean life span was reduced in 12 and the splenic platelet pool increased, often markedly so, in 15. However, the platelet count was not significantly related to mean bile span, the splenic platelet pool, ...

introduction: the field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. stem cell therapy seems to be a new treatment option for some diseases. so, tracking the distribution of stem cells is crucial to their therapeutic use. based on this fact we labeled human mesenchymal stem cells (mscs) with 111in- oxine for the first time in our coun...

large quantities of radiopharmaceuticals prescribed for treatment and diagnosis are excreted through kidney. therefore, radiation unwanted dose is created in kidney. as a result, exact calculation of prescribed radiopharmaceuticals amount is important. monte carlo method is used for simulation of radiation transport in body due to random nature of radiation. in this research, for the first time...

The purpose of this study is to conduct a thorough examination the direct and indirect impacts increasing quantity heavy WO3 on gamma-ray transmission, shielding mechanical properties for some selected barium-phosphate-tungsten glasses. Accordingly, oxides with chemical formula (50-x)P2O5-50BaO-xWO3 (x = 0.0(S1), 5.0(S2), 10(S3), 15(S4)) mol% was evaluated using Makishima-Mackenzie model. Next,...