Using third harmonic generation (THG) microscopy, we demonstrate that granularity differences of leukocytes can be revealed without a label. Excited by a 1230 nm femtosecond laser, THG signals were generated at a significantly higher level in neutrophils than other mononuclear cells, whereas signals in agranular lymphocytes were one order of magnitude smaller. Interestingly, the characteristic ...

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A frequent immune-related adverse event of checkpoint-inhibitor (CPI) treatment, which manifests as depigmented spots on the skin is known Vitiligo-like depigmentation (VLD). The aim this study was to further characterize clinical, biological and prognostic features melanoma patients with VLD under CPI-treatment explore whether they exhibit a characteristic immune response profile in peripheral...

1Laboratory of Antigen Targeting to Dendritic Cells, Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, Brazil 2Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP/EPM), 04023-062 São Paulo, SP, Brazil 3Emory Vaccine Center and Department of Microbiology and Immunology, Emory University Sc...

ANALYSIS OF HISTONES IN XENOPUS LAEVIS PART I: A DISTINCT INDEX OF ENRICHED VARIANTS AND MODIFICATIONS EXISTS IN EACH CELL TYPE AND IS REMODELED DURING DEVELOPMENTAL TRANSITIONS David Shechter*, Joshua J. Nicklay†, Raghu K. Chitta†, Jeffrey Shabanowitz†, Donald F. Hunt†°, and C. David Allis* *The Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065; Department of †Che...

During May 1988 a 1230-m ice thickness profile was drilled across a floe in Fram Strait. The probability density function of this data set corresponds closely to extensive ice draft measurements from submarines and the thickness distribution of floes sampled randomly in the area. The observed similarity is attributed to the topography of the pack ice in Fram Strait where each floe is composed o...