enantio-3-Hydroxyambrox derivatives were obtained through combined chemical and microbiological methods from ent-12-o×o-13-epi-manoyl oxides. Regioselcctive and stereoselcctive reduction ofthe ¢~bonyl group at C-3 of ent-3,12-dioxo-13-epi-manoyl oxide was card ed out with Baker "s yeast. Regioselcctive acetyl ation of ent-3,12-dihydxoxy-13-epi-manoyl oxide was accomplished with Candida cylindra...

hantzsch 1 ,4- dihy&opyridines; are rapidly oxidized to the corresponding pyridine derivatives using zinc chlorochromate nonahydrate [zn(c1cro ) .9h o] in dichloromethane at room temperature. in addition to aromatization, no loss of the 4- substituent is observed

Syntheses of a metabolite of the second messenger myo-inositol 1,4,5-trisphosphate, myo-inositol 1,4bisphosphate, and an analogue, the 1,4-bisphosphorothioate, are reported, by using phosphite chemistry on (± )1,2: 4,5-di-isopropylidene-myo-inositol. The synthesis of (± )1,2: 4,5-di-isopropylidene 3,6-bis[di-(2cyanoethyl)]phosphite provides an intermediate that can be oxidized to either the cor...

A simple, fast, efficient and environmentally friendly method for synthesis of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives was developed using zeolite HY. Two component cyclolcondensation of 1,2-phenylenediamine (o-phenylenediamine) and commercially available carboxylic acids catalyzed by zeolite HY without any solvent, under microwave irradiation led to formation...

A series of bicyclic nucleosides containing a triazolyl-carbohydrate moiety were synthesized and their antitumor activity in vitro for human cancer cell lines was also tested. Compound 11 was synthesized efficiently with 3,6-anhydro sugar 7 as raw material, while compound 7 was prepared from 1,2;5,6-di-O-isopropylidene-α-d-glucose. Compounds 12a-e were synthesized by treating compound 11 with a...