Tamoxifen was evaluated as initial hormone therapy for metastatic breast cancer in 85 premenopausal patients. Tamoxifen responders continued on tamoxifen, while tamoxifen failures and initial responders who later progressed were to receive ovarian ablation next. Of 74 evaluable patients, 5 had complete responses (CR) and 15 had partial responses (PR) while 12 remained stable (ST), giving respon...

We reported previously that calorie restriction (CR) delays spontaneous carcinogenesis in p53-deficient (p53-/-) mice, suggesting that CR modulates carcinogenesis by p53-independent mechanisms. To further evaluate the role of p53, we monitored tumor development in p53-/- and wild-type (p53+/+) mice fed ad libitum (AL) or a CR regimen (60% of AL calorie intake). CR delayed tumor mortality in p53...

metal pollution has become one of the most serious environmental problems resulting from human activity. phytoremediation utilizes plants to uptake contaminants and can potentially be used to remediate metal-contaminated sites. the present study investigates heavy metal uptake (cd, cr, and ni) from soil by different organs of populus alba and morus alba. for this purpose, cd (40, 80, and 160 mg...

Whether the well-known metabolic switch AMP-activated protein kinase (AMPK) is involved in the insulin-sensitizing effect of calorie restriction (CR) is unclear. In this study, we investigated the role of AMPK in the insulin-sensitizing effect of CR in skeletal muscle. Wild-type (WT) and AMPK-α2(-/-) mice received ad libitum (AL) or CR (8 weeks at 60% of AL) feeding. CR increased the protein le...

BACKGROUND The potential risks associated with hip resurfacing arthroplasty (HRA) are controversial and underestimated. The aim of this study was to explore intermediate-term trends for the levels of cobalt (Co), chromium (Cr), and molybdenum (Mo) ions after HRA. METHODS Forty patients who underwent HRA from October 2005 to December 2010 were recruited to this study. The serum levels of metal...

We characterized the effects of calorie restriction (CR) on the expression of key glycolytic, gluconeogenic, and nitrogen-metabolizing enzymes in mice. Of the gluconeogenic enzymes investigated, liver glucose-6-phosphatase mRNA increased 1.7- and 2.3-fold in young and old CR mice. Phospho enolpyruvate carboxykinase mRNA and activity increased 2.5- and 1.7-fold in old CR mice. Of the key glycoly...

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. With current treatment strategies, almost 80% of AML patients (18-60 years) will achieve com‐ plete remission (CR). However, approximately 50% of these patients will experience a re‐ lapse, resulting in a five-year survival rate of only 35%-40% [1]. This implies that despite CR, in these patients a number of cance...

Dhahbi, Joseph M., Patricia L. Mote, John Wingo, John B. Tillman, Roy L. Walford, and Stephen R. Spindler. Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E352–E360, 1999.—We characterized the effects of calorie restriction (CR) on the expression of key glycolytic, gluconeogenic, and nitrogen...