We assessed the ability of cryptophycin 52 (LY355703), a novel antimicrotubule, to induce growth arrest and apoptosis in prostate cancer cell lines and investigated potential molecular mechanisms of death. LNCaP (androgen-dependent) and DU-145 (androgen-independent) cells accumulated in G(2)-M phase of the cell cycle and progressively acquired sub-G(0)-G(1) DNA content after 48 h of exposure to...

The effect of base temperature variation on the heat transfer from unsteady state annular heat sink of cooling microelectronic device. Three types of the base temperature variation equations are taken in the present study. The Sine wave variation, Cosine wave variation & exponential variation of the base temperature. The finite element technique based on Galerkin method with axisymmetric rectan...

There is accumulating evidence that some biochemical pathways observable by magnetic resonance spectroscopy, e.g., citrate acid and phospholipid metabolism, are altered in human prostate cancer. Four well-established human prostate cancer cell lines were therefore studied with magnetic resonance spectroscopy to compare differences in metabolic content with tumor biological behavior. Herein we d...

Prostate cancer (PCa) patients receiving the androgen ablation therapy ultimately develop recurrent castration-resistant prostate cancer (CRPC) within 1-3 years. Treatment with caffeic acid phenethyl ester (CAPE) suppressed cell survival and proliferation via induction of G1 or G2/M cell cycle arrest in LNCaP 104-R1, DU-145, 22Rv1, and C4-2 CRPC cells. CAPE treatment also inhibited soft agar co...

Background b-lapachone, a DNA repair inhibitor, has been recognized as important prototype with activity against cancer cells devoided of cytotoxicity in non-tumor cells. NQO1 is a reductive enzyme that is important for the activation of many bioreductive quinones. Thus, differential levels of NQO1 in tissues, including tumors, can provide a target for an enzyme-directed approach to cancer ther...

Background: PT-112 is the first pyrophosphate-platinum conjugate under phase 1/2 clinical development, with activity against heavily pretreated solid tumors including metastatic castration-resistant prostate cancer (PC). Prior work has shown that causes mitochondrial stress, may be selective to cells defects, and promotes robust immunogenic cell death. Here, we sought explore if differential me...

This paper reports findings from an AHRC-funded project into the use of more than one language in research projects. Using 35 seminar presentations and 25 researcher profiles, we investigated how researchers from differing disciplines became aware of the possibilities, complexities, and emerging practices of researching where more than one language is used: for example, in initial research desi...

Variations of heavy metals concentrations (Pb, Zn, Ni and Cd) in suspended matter as well as the physical properties (temperature, salinity, dissolved oxygen and pH) at five coastal sites and one reference station (offshore) were measured on seasonal base of the year 2005. Seasonal variations of seawater temperature, salinity, pH and dissolved oxygen were significant different, meanwhile; spati...

ت ُـ ا ةيباسحلا جماربلا لامعتسا نع ةجتانلا ةيلعافلا سايقل ةيّقيبطت تانوّكم ةساردلا هذه ددّح ةعوفدمل ةيتامولعم ةيمآ دوجوب يبيرقتلا قطنملا ةيرظن ىلع ةزكترملا هيجوتلاو ةرطيسلا ةمظنأ ةسدنه ىلإ ةفداه . نإ اعم دوجوب اهلامعتسا لجلأ ةهجوم ةيّسايقلا تانوّكملا ةيطّخ ريغو ةدقعم ةيباسح تلاد . و ثحبت ةساردلا هذه نم ةيّسايقلا تانوّكملا لامعتسا يف اهدامتعا بجاولا ةقيرطلا يف اًضيأ أ نم فلتخم ددع نيب ليضفتلا لج تامولعملا...

1 نارهت يكشزپ مولع هاگشناد ،تشادهب هدكشناد ،تشادهب شزومآ دشرا يسانشراك يوجشناد ناريا ، 2 لوئسم هدنسيون : رايداتسا هورگ نارهت يكشزپ مولع هاگشناد ،تشادهب هدكشناد ،تشادهب شزومآ ، ناريا . يكينورتكلا تسپ : [email protected] 3 نارهت يكشزپ مولع هاگشناد ،تشادهب هدكشناد ،هيذغت هورگ رايداتسا ناريا ، 4 رامآ هورگ رايداتسا يضاير و ، ريدم تاقيقحت زكرم ي ،يناتسراميب ت يناسر علاطا و تيريدم هدكشن...