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OBITUARY G. E. Gask, C.M.G., D.S.O., F.R.C.S. ....193 Sir Lenthal Cheatle, K.C.B., C.V.O., F.R.C.S. 194 J. H. Rawlinson, F.R.C.S.Ed. ............ 194 W. J. Logie, M.B. ................... 195 C. R. Worthington, B.ch. ..........I..... 195 E. J. Davis-Taylor, M.B. ..............195 C. W. Gurd, M.B. ................... 195 LEADING ARTICLES The Old Minister and the New ........ 175 The B,2 Group of...
ACTH “big ACTH”, 175 “little ACTH”, 175 Acetyl strophanthidin, radioimmunoassay, 221 Adenylate cyclase activity, measurement by radioimmunoas8ay, 312 beta-Adrenergic binding sites catecholamine assay vehicle, 259 heart muscle membrane fractions, 259 Adrenergic receptors, current concepts, 259 alpha-Adrenergic receptors, catecholamines, 261 beta-Adrenergic receptors, catecholamines, 261 Aldoster...
The genomes of the aerobic methanotrophs "Methyloterricola oryzae" strain 73aT and Methylomagnum ishizawai strain 175 were sequenced. Both strains were isolated from rice plants. Methyloterricola oryzae strain 73aT represents the first isolate of rice paddy cluster I, and strain 175 is the second representative of the recently described genus Methylomagnum.
INTRODUCTION Recent studies have demonstrated the role of the interleukin 28B (IL28B) polymorphisms in predicting treatment induced and spontaneous clearance from Hepatitis C virus (HCV) infection, suggesting the possibility of tailored therapy in HCV infected patients. Genome-wide association studies have shown that single nucleotide polymorphisms (SNPs) near IL 28B gene on chromosome 19 are s...
BACKGROUND AND PURPOSE In vivo and vitro studies revealed the activation of thrombin and the complement system in vascular lesion formation during the process of atherosclerosis, along with pathological proliferation of smooth muscle cells. We examined the effect of the synthetic serine protease inhibitor FUT-175 (developed as a potent inhibitor of thrombin and the complement system) on vascula...
PURPOSE To establish the maximum tolerated dose of lonafarnib, a novel farnesyltransferase inhibitor, in combination with paclitaxel in patients with solid tumors and to characterize the safety, tolerability, dose-limiting toxicity, and pharmacokinetics of this combination regimen. EXPERIMENTAL DESIGN In a Phase I trial, lonafarnib was administered p.o., twice daily (b.i.d.) on continuously s...
BACKGROUND The targets and mechanisms of human immunity to malaria are poorly understood, which poses a major barrier to malaria vaccine development. Antibodies play a key role in human immunity and may act by inhibiting receptor-binding functions of key merozoite invasion ligands. Antibodies to the major invasion ligand and vaccine candidate, erythrocyte-binding antigen 175 (EBA-175), have bee...
By making use of the MOS diode theory, the carrier, and current distribution, as well as the mobility in a MOS device is evaluated. Simple analytical expressions are used for parameters like mobility, carrier concentration, and transversal electric field. Agreement between experimental and simulated results from an LDD MOSFET and an n-well resistance is in agreement, probing this approach is su...
Myostatin (MSTN) is a potent negative regulator of skeletal muscle growth. MSTN propeptide (MSTNpro) inhibits MSTN binding to its receptor through complex formation with MSTN, implying that MSTNpro can be a useful agent to improve skeletal muscle growth in meat-producing animals. Four different truncated forms of pig MSTNpro containing N-terminal maltose binding protein (MBP) as a fusion partne...
II. BIOTECHNOLOGY AND PROPRIETARY RIGHTS .............................173 A. Mining Diamond ......................................................................173 B. The Bayh-Dole Act ...................................................................174 C. Gene Patents ............................................................................174 D. Research Tools and Experimental Use .......
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