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Myeloid-derived suppressor cells (MDSCs) play a critical role in regulating immune responses in cancer and other pathological conditions. Mechanism(s) regulating MDSC differentiation and function is not completely clear, especially epigenetic regulation. In this study, we found that MDSCs express retinal non-coding RNA3 (RNCR3), and the expression in MDSCs is upregulated by inflammatory and tum...

Breast cancer is a major public health problem all over the world, and the current treatment strategies are not potent enough for some patients, especially those with triple-negative breast cancer (TNBC). Recent studies have demonstrated that microRNAs (miRNA) play vital roles in the development of TNBC. In this study, we found that miR-185 was strongly downregulated in TNBC tissues and cell li...

BACKGROUND TrkB-T1 is a BDNF receptor lacking a tyrosine kinase domain that is highly expressed in astrocytes and regulates BDNF-evoked calcium transients. Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide. METHODS In a microarray screening study (N = 8), we interrogated all known microRNA in the frontal ...

Solution. The prime factorization of 185 is 5*37. Given a group of order 185, Let n5 be the number of subgroups of order 5 and n37 the number of subgroups of order 37. Since subgroups of order 5 and 37 will be Sylow subgroups, by the Sylow Theorems n5 and n37 have to be 1 (mod 5) and 1 (mod 37), respectively and divide 37 and 5, respectively. Hence, n5 = n37 = 1 and the 5 and 37 Sylow subgroups...

Mammalian circadian rhythm is observed not only at the suprachiasmatic nucleus, a master pacemaker, but also throughout the peripheral tissues. Investigation of the regulation of clock gene expression has mainly focused on transcriptional and posttranslational modifications, and little is known about the posttranscriptional regulation of these genes. In the present study, we investigate the rol...