The 3-amino-2-methylpyridine derivative 1 was identified as ligand of the BAZ2B bromodomain by automatic docking of nearly 500 compounds, selected on the basis of previous fragment hits. Hit expansion by two in silico approaches, pharmacophore search followed by docking, and substructure search resulted in five additional ligands. The predicted binding mode of the six 3-amino-2-methylpyridine d...

In the mol-ecule of the title compound, [CdCl(2)(C(24)H(20)N(2))(2)], the Cd(II) centre has a distorted tetra-hedral coordination geometry defined by two chloride ions and two pyridine N atoms of the monodentate 2-[(triphenyl-meth-yl)amino]pyridine ligands. Weak intra-molecular N-H⋯Cl hydrogen bonds help to establish the three-dimensional architecture.

a thin-layer chromatography method has been developed and evaluated for the separation and determination of lysine and methonine in a mixture of amino acids obtained from acid or enzyme hydrolysis of protein. the solvent systems were (a) ethanol-ether, (b) phenol-water, (c) ethyl methyl ketone-pyridine-distilled water-glacial acetic acid. procedures in all the three stages were in the same dime...

A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

The title salt, 2C7H11N2 (+)·2C7H4NO4 (-)·3H2O, crystallized with two anions and two cations in the asymmetric unit, together with three water mol-ecules. Both 4-di-methyl-amino-pyridinium cations are protonated at their pyridine N atoms with the plane of the N(CH3)2 hetero atoms inclined to the pyridine ring by 4.5 (2) and 1.4 (2)°. In the 2-nitro-benzoate anions, the carboxyl and nitro groups...

The reaction of a cobalt(II) salt with 4-(dimethyl-amino)pyridinium hydro-bromide perbromide yielded the title compound, (C(7)H(11)N(2))[CoBr(3)(C(7)H(9.1)Br(0.9)N(2))]. In the anion, the Co(II) atom is coordinated in a distorted tetra-hedral geometry by three Br atoms and the pyridine N atom of a bromine-substituted 4-(dimethyl-amino)pyridine mol-ecule, whose formation probably results from an...