نتایج جستجو برای: 2 methylpropyl ethanoate
تعداد نتایج: 2525279 فیلتر نتایج به سال:
In this study, an in-situ piezoelectric effect is integrated into a photoactive region to develop self-powered ultraviolet photodetector based on p-n junction of ZnO@Polyvinylidene fluoride (PVDF) and poly [9,9-dioctylfluorene-co-N-[4-(3-methylpropyl)]-diphenylamine] (TFB). A ZnO@β-PVDF nanocomposite fabricated using PVDF with the β-phase as polymer matrix ZnO nanoparticles fillers. The strong ...
Diazepam-binding inhibitor (DBI) is a 9-kDa polypeptide that colocalizes in glial, adrenocortical, and Leydig cells with the mitochondrial DBI receptor (MDR). By binding with high affinity to the MDR, DBI and one of its processing products--DBI-(17-50)--regulate pregnenolone synthesis and have been suggested to participate in the immediate activation of adrenal steroidogenesis by adrenocorticot...
BACKGROUND AND OBJECTIVES The potential anticancer agent 1-(2-chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide (PK11195), a translocator protein (18KDa) (TSPO) ligand, facilitates the induction of cell death by a variety of cytotoxic and chemotherapeutic agents. Primary chronic lymphocytic leukemia (CLL) cells overexpress TSPO. The aim of this study was to examine the effects of PK11195 o...
Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study
UNLABELLED Inflammatory mechanisms, like microglial activation, could be involved in the pathogenesis of Alzheimer's disease (AD). (R)-[(11)C]PK11195 (1-(2-chlorophenyl)-N-methyl-N-1(1-methylpropyl)-3-isoquinolinecarboxamide), a positron emission tomography (PET) ligand, can be used to quantify microglial activation in vivo. The purpose of this study was to assess whether increased (R)-[(11)C]P...
We investigated the microglial response to progressive dopamine neuron degeneration using in vivo positron emission tomography (PET) imaging and postmortem analyses in a Parkinson's disease (PD) rat model induced by unilateral (right side) intrastriatal administration of 6-hydroxydopamine (6-OHDA). Degeneration of the dopamine system was monitored by PET imaging of presynaptic dopamine transpor...
Launaea (Lactuca) taraxacifolia also known as wild (African) lettuce is anethno-pharmacologically significant plant of the Asteraceae family. The was carefully chosen for this study due to its extensive use in traditional herbal practices treat a wide range ailments. extraction leaves phytochemical screening carried out by subjecting air dried pulverized materials into trichloromethane, normal ...
In the title compound, C(16)H(19)N(5)O(6), two intramolecular N-H⋯O hydrogen bonds help to establish the conformation. In the crystal, intermolecular N-H⋯O links result in chains propagating in [010].
Methamphetamine is a popular addictive drug whose use is associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic and serotonergic systems of the brain. Methamphetamine-induced neuropathology is associated with increased expression of microglial cells that are thought to participate in either pro-toxic or protective mechanisms in the brain. Although reactive microg...
Determination of pharmacokinetic properties in the intact animal remains a major bottleneck in drug discovery. Cassette dosing involves administration of a cocktail of drugs to individual animals. Here we describe the cassette dosing properties of a 107-membered library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 (CDK2) inhibitors. A three-step parallel synthesis approach produced ...
In lamina II of the spinal dorsal horn, synaptic inhibition mediated by ionotropic GABAA and glycine receptors contributes to the integration of peripheral nociceptive messages. Whole-cell patch-clamp recordings were performed from lamina II neurons in spinal cord slices to study the properties of miniature IPSCs (mIPSCs) mediated by activation of GABAA and glycine receptors in immature ( 30 d)...
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