SB-209247 [(E)-3-[6-[[(2,6-dichlorophenyl)-thio]methyl]-3-(2-phenylethoxy)-2-pyridinyl]-2-propenoic acid], an anti-inflammatory leukotriene B4 receptor antagonist, was associated in beagle dogs but not male rats with an inflammatory hepatopathy. It also produced a concentration-dependent (10-1000 microM) but equal leakage of enzymes from dog and rat precision-cut liver slices. The hepatic metab...

A Sarvate–Beam Triple System SB(v, 3) is a set V of v elements and a collection of 3–subsets of V such that each distinct pair of elements in V occurs in i blocks, for every i in the list 1, 2, . . . , ( v 2 ) . In this paper, we completely enumerate all Sarvate-Beam Triple Systems for v = 5 and v = 6. (In the case v = 5, we extend a previous result of R. Stanton [8].) 1 Sarvate–Beam Designs Th...

BACKGROUND Suicidal patients admitted to a psychiatric hospital are considered to be at risk of suicidal behavior (SB) and suicide. The present study aimed to seek predictors of SB recurrence of the high-risk patients by examining their post-hospitalization course. METHOD The design was 2-year prospective follow-up study of patients consecutively admitted with SB to a psychiatric center in To...

BACKGROUND Coronary hemodynamics and physiology specific for bifurcation lesions was not well understood. To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesions computational fluid dynamics simulations were performed. METHODS A parametric model representing a left anterior descending-first diagonal coronary bifurcation lesion was cr...

The asymmetric unit of the title compound, (C(6)H(14)N)(2)[SbCl(5)], contains one cation and half of the anion on a special position (specifically, the Sb(III) ion and three chloride anions are situated on a mirror plane). In the [SbCl(5)](2-) unit, the Sb(III) ion is coordinated by five chloride anions [Sb-Cl = 2.3721 (11)-2.6656 (12) Å] in a distorted square-pyramidal geometry. However, one c...

The mechanism of the antidepressant-like activity of the selective 5-hydroxytryptamine(6) (5-HT(6) receptor antagonist N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide (SB-399885) was studied in the forced swim test in rats. SB-399885 administered intraperitoneally at a single dose of 10 mg/kg potently shortened the immobility time in rats. That potential antid...

Positron annihilation measurements, supported by first-principles electron-structure calculations, identify vacancies and vacancy clusters decorated by 1-2 dopant impurities in highly Sb-doped Si. The concentration of vacancy defects increases with Sb doping and contributes significantly to the electrical compensation. Annealings at low temperatures of 400-500 K convert the defects to larger co...

Objectives: Sleep Bruxism (SB) is a movement disorder identified by tooth grinding and rhythmic masticatory muscle activity (RMMA). It is often associated with body movements and sleep arousals. Increases in autonomic sympathetic activities that characterize sleep arousal precede SB. These events include an augmentation of the following variables: sympathetic cardiac activity (-4 minutes), elec...

The novel metallic compound Na(6)TlSb(4) consists of four-membered TlSb(3) rings joined by pairs of Sb atoms into Tl(2)Sb(8) units, the last of which is further interconnected into 1D anionic chains via Tl-Tl bonds. The contrast of its metallic conductivity with that of the 2 - e(-) poorer, electron precise, and semiconducting Zintl phase K(6)Tl(2)Sb(3), which has virtually the same anionic net...

To investigate an amorphous structure of Ge(2)Sb(2)Te(5) that satisfies the 8-N rule (so-called 'ideal glass'), we perform alternative melt-quench simulations on Si(2)As(2)Se(5) and replace atoms in the final structure with Ge-Sb-Te. The resulting structures have salient features of the 8-N rule such as the tetrahedral configuration for all Ge atoms and the localized Te lone pairs at the valenc...