Previous studies identified a family of organic anion transport proteins (OATPs), many of which have C-terminal PDZ binding consensus sequences. In particular, the C-terminal four amino acids of Oatp1a1, a transporter on rat and mouse hepatocytes, comprise a consensus binding site for PDZK1. In PDZK1 knockout mice and in transfected cells where PDZK1 expression was knocked down, Oatp1a1 accumul...

BACKGROUND Obesity is a major risk factor for the development of type 2 diabetes mellitus. Surgery is one of the most effective treatments for morbid obesity. In a prospective cohort study, we examined the effects of Laparoscopic Gastric Plication (LGP) as a new restrictive technique on remission of type 2 diabetes mellitus. METHODS During six years of study from June 2007 through December 20...

The fluid distribution as a function of height in transition zones is often very complex. This may be due to movement of water-oil contact, tilting of the reservoir at some point in time, leak of fluid out of the reservoir zone or complex inflow during secondary migration. The resultant fluid distribution seen in saturation logs may be difficult to model. In this paper we address the changes in...

The most basic and fundamental element of the psalms is their: expression of continual total and exclusive trust in God. This element is most fully expressed in Psalm 62. This psalm, as well as Psalms 4, 16, 27 and 131, is a psalm of trust. Each expresses the same firm hope in God's ability to help his faithful ones become "more than conquerors." Several scholars argue that the psalms of trust ...

Until the early 1970s, the cause of most gastroenteritis was unknown. Cases were attributed to the known infectious agents, mainly bacteria, and many other causes, including teething, weaning, diet, old age, drugs, and malnutrition. In 1972, immune electron microscopy of fecal specimens derived from an outbreak at a school in Norwalk, Ohio, USA, resulted in the identification of Norwalk virus, ...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine metabolic disorders of reproductive age women. The main signs of PCOS are as follows: androgen excess, menstrual dysfunction, infertility, obesity, and other numerous health problems. By different authors, the disorder affects 2-28% of reproductive age women. Materials and Methods: Polycystic ovary syndrome is char...