The mitochondrial respiratory chain, including mitochondrial complex II, has emerged as a potential target for cancer therapy. In the present study, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), DT-010, was synthesized. Our results showed that DT-010 is more potent than its parental compounds separately or in combination, in inhibiting the proliferation of MCF-7 and MDA-MB...

Ports constitute a significant influence in the economic activity coastal areas through operations and infrastructures to facilitate land maritime transport of cargo. are located multi-dimensional environment facing ocean river hazards. Higher warming scenarios indicate Europe’s ports will be exposed higher risk due increase extreme sea levels (ESL), combination mean level, tide, storm surge. L...

AIM To validate a previously developed prediction model for vaginal birth after cesarean (VBAC) using a Japanese cohort. METHODS We performed a cohort study of all term pregnant women with a vertex position, singleton gestation, and one prior low transverse cesarean delivery attempting a trial of labor between April 1985 and March 2010. Variables necessary for the prediction of successful VBA...

We study how the eightfold-degeneracy in the (θ13, δ) plane observed in γ ∼ 100 β-beams can be reduced by periodically changing the ions in the storage ring. This “ions cocktail” allows to change the neutrino energy, at fixed γ, by choosing ions with different decay energies. We propose to combine the standard He and Ne beams with Li and B ones. These latter two ions have peaked νe → νμ oscilla...

In this paper, the seismic collapse probability of special steel moment-resisting frame (SSMRF) structures under near fault pulse-like and far fault ordinary ground motions is evaluated through fragility analysis. For this purpose, five sample frames with 3 to 15 stories are designed and imposed to the ground motion excitations with different characteristics. Fragility curves are derived for th...

We investigated 2 Chinese families with dyschromatosis symmetrica hereditaria (DSH) and search for mutations in the adenosine deaminase acting on RNA1 (ADAR1) gene in these 2 pedigrees. We performed a mutation analysis of the ADAR1 gene in 2 Chinese families with DSH and reviewed all articles published regarding ADAR1 mutations reported since 2003 by using PubMed. By direct sequencing, a 2-nucl...

This work represents a numerical study of the thermal activation for dislocation glide of the [100](010) slip system in MgSiO3 post-perovskite (Mg-ppv) at 120 GPa. We propose an approach based on a one-dimensional line tension model in conjunction with atomic-scale calculations. In this model, the key parameters, namely, the line tension and the Peierls barrier, are obtained from density functi...

The title compound (also know as azorellanone), C(20)H(32)O(2), is built up from three fused carbocycles, one five-membered ring and two six-membered rings. The five membered-ring has an envelope conformation, whereas the six-membered rings have a distorted half-chair and a twist-boat conformation. In the crystal, mol-ecules are linked by O-H⋯O inter-actions into zigzag chains with graph-set no...