The diffusion of H2O2 into the cytoplasm from peroxisomes during high rates of peroxisomal beta oxidation of fatty acids was studied in perfused livers from rats treated with the hepatocarcinogenic peroxisome proliferator, nafenopin. Efflux of oxidized glutathione (GSSG) into the bile was used as a measure of increased H2O2 supply for cytoplasmic glutathione peroxidase. Male F-344 rats were giv...

This study aimed to determine the frequency of fascioliasis in animals slaughtered slaughterhouses province Andahuaylas and financial loss due seizure livers. The research was quantitative at a basic level, analytical design, observational type, cross-sectional. It carried out between October December 2016 districts Andahuaylas, San Jerónimo, Talavera. At same time, retrospective corresponding ...

BACKGROUND Livers derived from donation after circulatory death (DCD) are increasingly accepted for transplantation. However, DCD livers suffer additional donor warm ischemia, leading to biliary injury and more biliary complications after transplantation. It is unknown whether oxygenated machine perfusion results in better preservation of biliary epithelium and the peribiliary vasculature. We c...

1. Livers from normal and alloxan diabetic rats were perfused in vitro with a medium in which the concentration of free fatty acid was maintained at relatively constant levels by the infusion of a complex of oleic acid and bovine serum albumin. Concentrations of free fatty acid up to 3.5 mM in the cell-free perfusate were attained. 2. Throughout the range of concentration of free fatty acid whi...

The hypothesis was tested that sequence diversity in breast cancer resistance protein (BCRP)'s cis-regulatory region is a significant determinant of BCRP expression. The BCRP promoter and intron 1 were resequenced in lymphoblast DNA from the polymorphism discovery resource (PDR) 44 subset. BCRP single nucleotide polymorphisms (SNPs) were genotyped in donor human livers, intestines, and lymphobl...

In recent years, there has been a shift in the donor demographics with an increase in donation after circulatory death (DCD). Livers obtained from DCD donors are known to have poorer outcomes when compared to donors after brainstem death and currently only a small proportion of DCD livers are used. This review outlines the recent technological developments in liver DCD donation, including clini...

The microsomal synthesis of docosahexaenoic acid (DHA) from radiolabeled eicosapentaenoic acid was tested in vitro using the livers of crab-eating monkeys. The test animals included 1 fetus (embryonic day 120), 2 neonates (full-term, embryonic day 165), and 2 adults. DHA was formed equally in the liver microsomes of each animal. Neonatal livers were found to contain higher percent of arachidoni...

Explanation.................................................................................................. 256 Evaluation for acceptable daily intake......................................................... 256 Biochemical aspects............................................................................... 256 Absorption, distribution, and excretion ...........................................