Persistent phosphors have the ability to emit light long after the excitation has ended, typically by using thermal energy to liberate previously trapped charges. Alternatively, also photons can be used for the detrapping, leading to optically stimulated luminescence (OSL). This particular field of phosphor research has seen a strong expansion over the past two decades, with a steady growth of ...

Fluoroquinolones antibiotics are effective intracellular antibiotics, and their activity depends on achieving appropriated concentrations. It is thought that to reach the intracellular environment, fluoroquinolones interacts with the membranes lipid bilayer and/or recognizes the membranous proteins like efflux pumps (1,2). Therefore, probing drug/lipid interactions at the molecular level repres...

Prostate cancer has become the most common in England, with 49 029 cases 2018 [[1]Prostate Cancer UK now commonly diagnosed England.2020https://prostatecanceruk.org/about-us/news-and-views/2020/1/prostate-cancer-now-most-commonly-diagnosed-cancer-in-englandDate accessed: June 24, 2021Google Scholar]. One eight men will be during their lifetime [[2]Prostate About prostate cancer: facts and figur...

ImmunotherapyVol. 13, No. 3 CommentaryFree AccessImmunity to glycan ?-Gal and possibilities for the control of COVID-19José de la Fuente, Christian Gortázar & Alejandro Cabezas-CruzJosé Fuente *Author correspondence: E-mail Address: [email protected]://orcid.org/0000-0001-7383-9649SaBio. Instituto Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ronda Toledo s/n, 13005 Ci...

Carrier dynamics in graphene films on CaF2 have been measured in the mid infrared region by femtosecond pump-probe spectroscopy. The relaxation kinetics shows two decay times. The fast time component is ~0.2 ps, which is attributed to the mixture of initial few ultrafast intraband and interband decay channels. The slow component is ~1.5 ps, which is primarily assigned to optical phonon-acoustic...

•Increased acylcholine as unique HIV-1 positive elite controllers (EC) feature•Physiological oxidative stress and inflammation profile in EC•Increased CCL4, CCL7, CCL20, NOS3 EC compared with HIV-ve control•CCR6-CCL20-dependent anti-HIV mechanism can play an essential role status are a rare but heterogeneous group of HIV-1-infected individuals who suppress viral replication the absence antiretr...

•TopBP1 assembles biomolecular condensates•Composition of TopBP1 condensates revealed by proximity proteomics•Phosphorylation induces condensation•TopBP1 condensation switches on ATR/Chk1 signaling and causes fork slowing ATR checkpoint is crucial for cellular responses to DNA replication impediments. Using an optogenetic platform, we show that TopBP1, the main activator ATR, self-assembles ext...

•Enantiotopic differentiation of dinitrile to all-carbon quaternary centers•Atom economic synthesis enantioenriched densely substituted pyridines•Zinc-promoted hetero-cyclometallation nickel with alkyne and nitrile•Broad scope, good enantioselectivity, excellent regioselectivity Pyridines are among the most significant heterocycles not only prevalently found in pharmaceuticals, natural products...

•Dynamic ligand exchange allows polar/radical mechanistic shift on a single metal core•Unlocks secondary alkyl electrophiles in Cu-catalyzed alkyne carboboration•Carbo- and heterocycles complex units incorporated at either reaction partner•Alkyne valorization into richly substituted, stereodefined tetrasubstituted alkenes The invention of novel approaches catalysis is inherent to the developmen...

We present a detailed transmission electron microscopy and electron diffraction study of the thinnest possible membrane, a single layer o f carbon atoms suspended in vacuum and attached only at its edges. Membranes consisting o f two graphene layers are also reported. We find that the membranes exhibit an apparently random spontaneous curvature that is strongest in single-layer membranes. A dir...