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CERN announced in January 1996 the detection of the rst eleven atoms of antimatter ever produced. The experiment w as based on a method proposed earlier by S. Brodsky, C. Munger and I. Schmidt, and which furthermore predicted exactly the number of atoms that were detected for the particular conditions of the experiment. The study of antihydrogen aords science the opportunity to continue researc...
The association of the histone deacetylase (HDAC) inhibitor valproate (VPA) with atypical antipsychotics has become a frequent treatment strategy for schizophrenia and bipolar disorder. Because the VPA doses administered are elevated, one cannot assume that the benefits of the VPA plus antipsychotic treatment are exclusively related to the covalent modifications of nucleosomal histone tails. We...
PURPOSE MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models. The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in humans administered with food on a once weekly schedule and to study the pharmacokinetics of oral MS-275. EXPERIMENTAL DESIGN Patients with refrac...
Breast cancer is a highly heterogeneous disease with distinct histologic subtypes. Targeted therapies such as endocrine therapy and growth factor receptor inhibitors have had a significant impact on the treatment of metastatic breast cancer patients. Unfortunately, resistance to these agents eventually occurs, and currently represents a significant clinical problem in the management of breast c...
Introduction: Histone deacetylase (HDAC) inhibitors have been found to reverse the epigenetic profile of some genes, including estrogen receptor (ER), epidermal growth factor receptor (EGFR), and retinoic acid receptor (RAR) -β2 (1). Here we have studied the metabolic effects of the HDAC inhibitor MS-275, the aromatase inhibitor letrozole, and their combination in vivo in the ER/PR/Her-2 negati...
Fluoride present in toothpaste at 1,100 µg/g is considered effective on caries control. However, under high cariogenic challenge due to increasing sugar exposure, higher fluoride concentration (5,000 µg/g) could be necessary to compensate the unbalance on caries process. This was tested in a pH-cycling regimen, which evaluated the effect of fluoride concentration relative to toothpaste on reduc...
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