mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

The atherosclerotic lesion is characterized by the presence of cholesterol-loaded foam cells. Chinese hamster ovary (CHO) cells do not normally store cholesteryl esters because low density lipoprotein (LDL) receptors are suppressed by exposure of these cells to LDL cholesterol. We transfected LDL receptor cDNA linked to the simian virus 40 early promoter into CHO cells (CHO 29) and found that L...

The Cancer is one of the world’s most devastating diseases. Doxorubicin (DOX) is an effective chemotherapeutic drug; however, its toxicity is a significant limitation in therapy. Due to the severe side effects of chemotherapy drugs, scientists have tried to load these drugs in nanocomposites. This paper describes a facile and low cost approach for preparation polymeric biodegradable nanohybrid ...

background: interferons with diffrent functions such as antiviral, antiproliferative and immunomodulatory actions are effctivemedications for a number of diseases. one of these new interferons (ifns) is interleukin-29 (il-29) belongs to the family of ifn-λ hasantiviral activity and its potent in accompanying with ifn-α in treatment of hcv infection has been evaluated (clinical trial phase ii).r...

BACKGROUND Clausena excavata Burm.f. is a shrub traditionally used to treat cancer patients in Asia. The main bioactive chemical components of the plant are alkaloids and coumarins. In this study, we isolated clausenidin from the roots of C. excavata to determine its apoptotic effect on the colon cancer (HT-29) cell line. METHOD We examined the effect of clausenidin on cell viability, ROS gen...

background and aim: colon cancer is the third most prevalent cancer in iran. prolonged colon inflammation is an important factor, in the development of colon cancer. ginger has anti-inflammatory properties due to its content of [6]-gingerol and hence can play a role in the prevention of colon cancer. in this research the effects of ginger extract on reducing expression of the cox-2 gene in ht-2...

We investigated the signaling pathways associated with microtubule interaction and apoptosis in U937 cells in vitro and in the U937 xenograft model in vivo by using 6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone (MJ-29). MJ-29 induced growth inhibition and cell death of leukemia cell lines (U937, HL-60, K562, and KG-1) in a dose- and time-dependent manner but did not obviously impair the vi...

Similar amounts of N-cadherin and cadherin-7, the prototypes of type I and type II cadherin, induced cell-cell adhesion in murine sarcoma 180 transfectants, Ncad-1 and cad7-29, respectively. However, in the initial phase of aggregation, Ncad-1 cells aggregated more rapidly than cad7-29 cells. Isolated Ncad-1 and cad7-29 cells adhered and spread in a similar manner on fibronectin (FN), whereas a...

Background: Numerous molecules in Papaveraceae family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a few cases. Objective: Numerous molecules in this family display interesting cytotoxic activities against tumor cell lines in vitro and hints of anticancer activities in vivo have been reported in a fe...