Synthesis of Substituted 2-[(2-chloro-4-oxo-3-phenylazetidin-1-yl)amino]-1-methyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile(6a-r) and 1-methyl-6-oxo-2-[(4-oxo-2-phenyl-1,3-thiazolidin-3-yl)amino]-4-phenyl-1,6-dihydropyrimidine-5-carbonitrile (7a-o)Derivatives was completed using aromatic aldehyde, ethylcyanoacetate thiourea in absolute ethanol as per the standard procedure.The complet...

The crystal structures of four indole derivatives with various substituents at the 2-, 3- and 5-positions of the ring system are described, namely, ethyl 3-(5-chloro-2-phenyl-1H-indol-3-yl)-3-phenyl-propano-ate, C25H22ClNO2, (I), 2-bromo-3-(2-nitro-1-phenyl-eth-yl)-1H-indole, C16H13BrN2O2, (II), 5-meth-oxy-3-(2-nitro-1-phenyl-eth-yl)-2-phenyl-1H-indole, C23H20N2O3, (III), and 5-chloro-3-(2-nitr...

Recent preclinical and clinical research has shown that almorexant promotes sleep in animals and humans without disrupting the sleep architecture. Here, the pharmacology and kinetics of [(3)H]almorexant binding to human orexin 1 receptor (OX(1))- and human orexin 2 receptor (OX(2))-human embryonic kidney 293 membranes were characterized and compared with those of selective OX(1) and OX(2) antag...