Rapid and reliable antibiotic susceptibility testing (AST) platform is highly desired to select the right antibiotics treat infectious disease at early stage. Here, we demonstrate rapid ASTs using nanoscale silicon ion-selective field-effect transistor sensors. Our sensors profile bacterial metabolic kinetics by monitoring metabolism induced acidification in growth media with absence presence o...

BACKGROUND The aim of this study was to investigate long-term renal function in HIV-infected adults initiating antiretroviral therapy (ART) with a CD4(+) T-cell count < 200 cells/mm³ in Africa. METHODS This was an observational analysis within the DART trial randomizing 3,316 adults to routine laboratory and clinical monitoring (LCM) or clinically driven monitoring (CDM). Serum creatinine was...

HANEW, K., SASAKI, A. and YOSHINAGA, K. Evidence for Endogenous Dopaminergic Control of OH Release in Man. Tohoku J. exp. Med., 1981, 135 (1), 103-108 In order to determine whether or not there is a tonic dopamine (DA) control of GH release, the effect of an anti-dopaminergic agent, sulpiride, on GH secretion was studied in 12 normal subjects. After the administration of sulpiride, serum concen...

BACKGROUND Previous data have shown that ghrelin-induced growth hormone (GH) secretion is augmented in women by exogenous but not by endogenous estrogens. The purpose of this study was to examine the response of GH to low-dose scheme of ghrelin administration in relation to physiological changes in estradiol levels during the normal menstrual cycle. METHODS Ten normally cycling women were stu...

A series of prey items of a given weight were offered to a spider. They were obligatory removed 1 min after the beginning of the attack, and their state noted afterwards. Venom is injected in small as well as in large prey. The prey had 37 to 520 % of the spider weight. The mortality rate of the prey is negatively and linearly correlated with their weight. When a prey weighs about 30 mg or more...

Dear Editor-in-Chief, In a recent letter, Das and Peters [1] have made the suggestion that dose rate is not an important factor in determining the effectiveness of endovascular brachytherapy. As we [2–4] and others [5] have argued earlier, we suggest here that the dose rate or, equivalently, the treatment time, is important. Das and Peters [1] correctly argue that if the irradiation time is muc...

BACKGROUND This study investigated the impact of renal dysfunction (RD) on long-term outcomes in elderly patients with acute coronary syndrome (ACS), and evaluated prognostic factors in elderly patients with ACS and RD. METHODS This longitudinal prospective study included 184 consecutive patients who were admitted with ACS between January 2009 and January 2010 and also had RD. Patients were d...