Although chronic Pseudomonas aeruginosa infection is the major cause of morbidity and mortality in cystic fibrosis (CF) patients, there is no approved vaccine for human use against P. aeruginosa. The goal of this study was to establish whether a multivalent vaccine containing P. aeruginosa type A and B flagellins as well as the outer membrane proteins OprF and OprI would promote enhanced cleara...

I consider an exact model of atomic spontaneous dipole emission and classical dipole radiation in a finite photonic band-gap structure. The full 3D or 2D problem is reduced to a finite 1D model, and then this is solved for analytically using algebraic matrix transfer techniques. The results give insight to the electromagnetic emission process in periodic dielectrics, quantitative predictions fo...

1.1.1. Definitions 1. Bounded Above (for a set): Let S ⊂ R. S is bounded above if ∃L ∈ R such that x ≤ L for all x ∈ S. L is called an upper bound for S. (Similar definition for bounded below and lower bound) 2. Bounded (for a set): Let S be a set. S is bounded if S is bounded above and bounded below. 3. Least Upper Bound (LUB) Axiom for R (for a set): Let S ⊂ R be bounded above. Then !∃L ∈ R s...

An optimal nutritional state is an important consideration in providing successful operative outcomes. Unfortunately, many aspects of surgery are not constructive to providing this. In addition, the metabolic and immune response to injury induces a catabolic state and insulin resistance, a known risk factor of post-operative complications. Aggressive insulin therapy post-operatively has been sh...

The change in frequency of cocaine self-administration as a function of the unit dose is widely assumed to represent a graded pharmacodynamic response. Alternatively, a pharmacological theory states that during maintained selfadministration, a quantal response occurs at a minimum maintained cocaine concentration (satiety threshold). Rats selfadministered cocaine at unit doses spanning an 8-fold...

Tseng, Y.C.1, Ho, G.D.2, Chen, T.T.W.3, Huang, B.F.4, Cheng, P.C.5, Chen, J.L.6 and Peng, S.Y.7* 1Institute of Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien, Taiwan 2Effpha Pharma Management Corp. Taipei Taiwan 3Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan 4Department of laboratory medicine, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan ...

The density functionals B3LYP, B3PW91, M062X, and CAM-B3LYP with the 6-311+G(d,p) basis set predict the cysteine sulfenic acid O-sulfenylation of the s-cis-ketoenol tautomer of 1,3-cyclohexanedione proceeds through a cyclic 14-membered transition state structure containing three water molecules.

in this study, the geometries of the [sininhn]q and [sicunhn]q clusters, (n = 4,5,6 and q = 0,+1,-1) complexes have been optimized to form complexes with four, five and six planar and nonplanarsubstituents, with negative, neutral or positive atomic charge, using density functionaltheory (dft) at b3lyp/6-311+g (3df, p) computational level and then their thermodynamicstability were investigated b...

This paper deals with the evaluation of lipophilicity expressed by logPow parameter ten barbiturate derivatives generally used as sedative-hypnotics based on Density Functional Theory (DFT) calculations. All geometry optimizations and frequency calculations have been carried out using DFT/B3LYP/ 6-311++G (d,p) basis set in gas phase also water n-octanol phases. Gibbs free energies solvation for...