Abstract Introduction Never events represent a huge cost burden to the NHS due litigation. One such event occurred at high-volume orthopaedic unit involving wrong implant being inserted into patient. An extensive investigation was undertaken which highlighted combination of human error in checking process and storage system. As result, local guidance developed ensure ‘prosthetic pause’ performe...

The heat shock protein 90 (HSP90) is overexpressed and highly associated with poor prognosis in many malignancies. However, the role of HSP90 in gastric cancer has not been thoroughly elucidated. The aim of this study is to investigate the relationship of HSP90 expression with clinicopathological parameters and prognosis in advanced gastric cancer, and estimate the alteration of HSP90 expressio...

A simulation by Zhang et al. [IUCrJ (2015), 2, 322-326] has demonstrated that utilizing serial crystallography may turn one-dimensional powder diffraction from multiphase polycrystalline samples into three-dimensional single-crystal diffraction patterns.

The precise arrangement of molecules within the thick filament, as well as the mechanisms by which this arrangement is specified, remains unclear. In this article, we have exploited a unique genetic interaction between one isoform of myosin heavy chain (MHC) and paramyosin in Caenorhabditis elegans to probe the molecular interaction between MHC and paramyosin in vivo. Using chimeric myosin cons...

Previous work has shown that four deletions in simian immunodeficiency virus (SIV), termed SD1a, SD1b, SD1c, and SD6, which eliminated sequences at nucleotide positions 322 to 362, 322 to 370, 322 to 379, and 371 to 379, respectively, located downstream of the primer binding site, impaired viral replication capacity to different extents. Long-term culturing of viruses containing the SD1a, SD1b,...