نتایج جستجو برای: 3a
تعداد نتایج: 12064 فیلتر نتایج به سال:
Bone tissue is densely innervated, and there is increasing evidence for a neural control of bone metabolism. Semaphorin-3A is a very important regulator of neuronal targeting in the peripheral nervous system as well as in angiogenesis, and knockout of the Semaphorin-3A gene induces abnormal bone and cartilage development. We analyzed the spatial and temporal expression patterns of Semaphorin-3A...
We used learning-to-rank methods for training ranking model. Due to the limited number of training queries, we split them and conducted 5-fold cross validation. We set the proportion of training and testing as 4 : 6. For the features used in learning the model, a total of 231 features that are from multiple information retrieval models with different parameter settings were adopted. For the bas...
BACKGROUND Induction of cellular senescence through activation of the p53 tumor suppressor protein is a new option for treating proliferative disorders. Nutlins prevent the ubiquitin ligase MDM2 (murine double minute 2), a negative p53 regulator, from interacting with p53. We hypothesized that cell senescence induced by Nutlin-3a exerted therapeutic effects in pulmonary hypertension (PH) by lim...
I f you can't help out during an emergency , it's better to get out of the way and let someone else take over. The same principle could apply to DNA repair; as Zhang et al. reveal, mutating DNA-dependent protein kinase (DNA-PK) blocks several repair pathways, resulting in the loss of hematopoietic stem cells (1). DNA-PK consists of a catalytic sub-unit (DNA-PKcs) and the DNA-binding proteins Ku...
The genome of foot-and-mouth disease virus (FMDV) differs from that of other picornaviruses in that it encodes a larger 3A protein (>50% longer than poliovirus 3A), as well as three copies of protein 3B (also known as VPg). Previous studies have shown that a deletion of amino acids 93 to 102 of the 153-codon 3A protein is associated with an inability of a Taiwanese strain of FMDV (O/TAW/97) to ...
A highly diverse population of neocortical GABAergic inhibitory interneurons has been implicated in multiple functions in information processing within cortical circuits. The diversity of cortical interneurons is determined during development and primarily depends on their embryonic origins either from the medial (MGE) or the caudal (CGE) ganglionic eminences. Although MGE-derived parvalbumin (...
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