PURPOSE: PSA doubling time (PSADT) is commonly used as an indication for salvage androgen deprivation therapy (ADT) for PSA failure following RT. Previously, we had shown that PSADT of <12 months is an important predictor of distant metastasis following 3DCRT using the ASTRO definition of BF. We sought to determine if this approach is still valid using the Phoenix definition. METHODS: Eligible...

Parotid gland cancer; 3DCRT; Postoperative radiotherapy techniques; Dose distribution Abstract Introduction: Postoperative radiotherapy of the parotid gland could be achieved with various radiotherapy techniques. However they irradiate differently the surrounding organs at risk (OARs) in particular the cochlea, oral cavity & contralateral parotid causing significant increase in the risk of oral...

PURPOSE To compare target dose distribution, comformality, normal tissue avoidance, and irradiated body volume (IBV) in 3DCRT using classic anatomical landmarks (c3DCRT), 3DCRT fitting the PTV (f3DCRT), and intensity-modulated radiation therapy (IMRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS Fifteen patients with LARC underwent c3DCRT, f3DCRT, and IMRT pla...

The purpose of this study was to compare three computed tomography (CT) images under different conditions-average intensity projection (AIP), free breathing (FB), mid-ventilation (MidV)-used for radiotherapy contouring and planning in lung cancer patients. Two image sets derived from four-dimensional CT (4DCT) acquisition (AIP and MidV) and three-dimensional CT with FB were generated and used t...

Introduction:   The aim of this study is to investigate the effect of respiratory motion during radiation therapy in patient with lung cancer and comparison of dosimetric parameters between Intensity modulation radiation therapy and three-dimensional conformal radiotherapy in lung cancer.   Materials and Methods:   Two CT scan was performred for each pati...

Whole breast external beam radiotherapy is an effective adjuvant treatment for early breast cancer, and was a key factor in the move from mastectomy to breast-conserving surgery for women with low-risk disease. The logical development from partial surgical removal of the breast is partial breast radiotherapy. Several methods of delivery have been investigated, but as yet none has been widely ac...

This paper describes a suite of optimization tools for radiation treatment planning within the Matlab programming environment. The data included with these tools was computed for real patient cases using a Monte Carlo dose engine. The formulation of a series of optimization models is described that utilizes this data within a modeling system. Furthermore, visualization techniques are provided t...

At the very start of their clinical training, radiation oncologists tend to embrace technology. The specialty draws a preponderance of technophiles to it, and those few who are not at first passionate about technology quickly become so. This has been especially true over the past 2 decades with the introduction of innovative therapies such as three-dimensional conformal radiation therapy (3DCRT...