introduction: attachment of blood and tissue cells to the extracellular matrix (ecm) is done with the help of specific joints, which are made between cells’ receptors and matrixes’ ligands. this interaction is vital for many biological activities such as cell migration, cancer development, and wound healing. the purpose of this study is to model a 3-dimensional cell by abaqus commercial softwar...

In this article, a mathematical model describing the growth orterminating myelogenous leukemia blood cancer's cells against naive T-celland eective T-cell population of body, presented by fractional dierentialequations. We use this model to analyze the stability of the dynamics, whichoccur in the local interaction of eector-immune cell and tumor cells. Wewill also investigate the optimal contro...

In this paper, a robust optimization approach is proposed to design a dynamic cellular manufacturing system (DCMS) under uncertainty of processing time of products. In addition, a mathematical model considering cell formation, inter-cell design and production planning under a dynamic environment (i.e., product mix and demand are changed in each period) is presented. Therefore, reconfiguration b...

in this paper, a mixed-integer linearized programming (minlp) model is presented to design a group layout (gl) of a cellular manufacturing system (cms) in a dynamic environment with considering production planning (pp) decisions. this model incorporates with an extensive coverage of important manufacturing features used in the design of cmss. there are also some features that make the presented...

Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of keratinocytes and immune cell infiltration. The IL-17-producing T cells play key role in psoriasis pathogenesis, while regulatory (Treg) are diminished during psoriatic inflammation. Current treatments largely focus on IL-17 IL-23, however, few studies have explored therapeutic drugs targeting an increase Treg to c...

Interleukin 4 (IL-4) expresses multiple biologic activities, including B cell, mast cell, and T cell stimulation. We showed that the incubation of resting splenocytes from C57BL/6 mice solely in purified native or recombinant mouse IL-4 results in the generation of lymphokine-activated killer (LAK) activity directed against fresh, syngeneic sarcoma cells. The precursor activated by IL-4 express...

Cell growth and lactose consumption profile of five Lactobacillus Strains: bulgaricus, casei, lactis, delbrueckii and fermentum has been investigated. Experiments of cell growth and substrate utilization were conducted in batch submerged culture of whey with added lactose and some other growth factors. Fitness assessment of experimental data on the cell growth and lactose consumption by Monod k...