PURPOSE Long-term elevation of metastasis suppressor gene expression in micrometastases represents a novel therapeutic strategy for breast and other cancers. We searched for well-tolerated compounds that could elevate Nm23 metastasis suppressor expression in metastatic human breast cancer cell lines. EXPERIMENTAL DESIGN MDA-MB-435 and MDA-MB-231 human breast carcinoma cells were treated with ...

Expression of chimeras, composed of portions of two different glucose transporter isoforms (GLUT-1 and GLUT-4), in CHO cells had indicated that the cytoplasmic NH2 terminus of GLUT-4 contains important targeting information that mediates intracellular sequestration of this isoform (Piper, R. C., C. Tai, J. W. Slot, C. S. Hahn, C. M. Rice, H. Huang, D. E. James. 1992. J. Cell Biol. 117:729-743)....

This work was aimed at comparing distribution of isoforms for polymorphic histone H1 variants H1.b and H1.z and variably abundant histone H1.d subtype between quail (Coturnix japonica) population selected for a high egg yolk cholesterol content and the control birds. The isoforms of histone H1.b (H1.b1, H1.b2) and histone H1.z (H1.z1, H1.z2) differed in their apparent molecular weights judging ...

Heparanase is the only mammalian endoglycosidase which has been widely implicated in cancer because of its capability to degrade heparan sulfate chains of heparan sulfate proteoglycans (HSPG). Specifically, the cell surface HSPG syndecan-1 and -4 (SDC1 and SDC4) are modulators of growth factor action, and SDC4 is implicated in cell adhesion as a key member of focal adhesion complexes. We hypoth...

From 2010 to 2013 in Japan, we isolated 11 swine influenza viruses (SIVs) from pigs showing respiratory symptoms. Sequence and phylogenetic analyses showed that 6 H1N1 viruses originated from the pandemic (H1N1) 2009 (pdm 09) virus and the other 5 viruses were reassortants between SIVs and pdm 09 viruses, representing 4 genotypes. Two H1N2 viruses contained H1 and N2 genes originated from Japan...

In a graph G, k disjoint paths joining a single source and k distinct sinks that cover all the vertices in the graph are called a one-tomany k-disjoint path cover of G. We consider a k-disjoint path cover in a graph with faulty vertices and/or edges obtained by merging two graphs H0 and H1, |V (H0)| = |V (H1)| = n, with n pairwise nonadjacent edges joining vertices in H0 and vertices in H1. We ...

Let M be a complete, finite-volume, orientable hyperbolic manifold having exactly one cusp. If we assume that π1(M) has no subgroup isomorphic to a genus-2 surface group, and that either (a) dimZp H1(M ;Zp) ≥ 5 for some prime p, or (b) dimZ2 H1(M ;Z2) ≥ 4, and the subspace of H(M ;Z2) spanned by the image of the cup product H (M ;Z2) × H(M ;Z2) → H(M ;Z2) has dimension at most 1, then volM > 5....

(Def. 2) lenpr2(h1) = lenh1 and for every n such that n ∈ dompr2(h1) holds pr2(h1)(n) = h1(n)2. Let us consider A, B, let f1 be a homogeneous quasi total non empty partial function from A∗ to A, and let f2 be a homogeneous quasi total non empty partial function from B∗ to B. Let us assume that arity f1 = arity f2. The functor ee f1, f2dd yields a homogeneous quasi total non empty partial functi...

Histamine caused a fall in blood pressure in anesthetized dogs and cats which was only partially attenuated by mepyramine (pyrilamine), a histamine type H1-receptor antagonist. Further treatment with burimide or metiamide, type H2-receptor antagonists, caused nearly complete attenuation of the response to histamine. Burimamide alone had no effect on vasodilatation produced by histamine in the d...

We previously compared the structure and motility suppressive capacity of nm23-H1 by transfection of wild type and site-directed mutant forms into breast carcinoma cells. Wild type nm23-H1 and an nm23-H1(S44A) (serine 44 to alanine) mutant suppressed motility, whereas the nm23-H1(P96S), nm23-H1(S120G), and to a lesser extent, nm23-H1(S120A) mutant forms failed to do so. In the present study wil...