Intrauterine growth restriction (IUGR) increases the risk for neurodevelopment delay and neuroendocrine reprogramming in both humans and rats. Neuroendocrine reprogramming involves the glucocorticoid receptor (GR) gene that is epigenetically regulated in the hippocampus. Using a well-characterized rodent model, we have previously shown that IUGR increases GR exon 1.7 mRNA variant and total GR e...

OBJECTIVE The aim was to compare the efficacy of plaque control and potential effects on gingival recession of the toothbrushes with angled and straight bristles. MATERIALS AND METHODS A total of 40 healthy dental students (25 females and 15 males; age range: 23-25 years) participated and two study groups were constituted. Participants were randomly distributed into two groups to use either a...

Levels of non-protein thiols (mostly glutathione, GSH), ascorbic acid (AA), and activities of the enzymes ascorbate peroxidase (AP), glutathione reductase (GR) and GSH S-transferase (GST) were determined in cell-free leaf extracts of acifluorfen-resistant and -sensitive tobacco plants. These parameters were examined also in detached leaves of the above plants exposed to acifluorfen stress. In l...

The purpose of this study was to determine the fracture resistance of 4 post and core systems. 40 extracted maxillary canines (for orthodontic reason) were used for this study. The samples were divided into 4 groups, which were: Group (1) Cast post luted with Rely X ARC; Group (2) Cast post cemented with zinc phosphate; Group (3) Fibre post luted with Rely X + Filtek Z-250 as core material; Gro...

A constant-temperature, constant density molecular-dynamics (MD) method is utilized to study the behavior of bond-orientational, translational and thermodynamic parameters in the solid, melting transition and fluid regimes of argon physisorbed onto graphite (Ar/gr) at complete coverage. For Ar/gr, completion occurs near r=1.26 in units of 0.0636 atoms/Å2, where r=1 corresponds to the complete E...

Oxidative stress is an important pathophysiological mechanism in nonalcoholic steatohepatitis (NASH). To assess whether there are relationships between oxidative stress and antioxidant enzymes in the development of NASH, we investigated oxidative stress by measuring serum malondialdehyde (MDA) and nitric oxide (NO) and antioxidant status by measuring serum glutathione (GSH), glutathione peroxid...

the interaction between nitrogen levels: 100, 150 and 175 kg ha-1, as ammonium sulfate (ams) and glyphosate: 1) 61.5 gr a.i. ha-1 sprayed in three parts, 30, 40 and 50 dap, 2) 61.5 gr a.i. ha-1 sprayed in two parts, 30 and 50 dap, 3) 86 gr a.i. ha-1 sprayed in three parts as level one, 4) 86 gr a.i. ha-1 sprayed in two parts as level two on broomrape shoot density and dry mater and tomato yield...

Mice (GR-i) bearing a transgene encoding a glucocorticoid receptor (GR) antisense RNA under the control of a neuron-specific neurofilament promoter were used to investigate the effects of a 4 week chronic mild stress (CMS) on the hypothalamo-pituitary-adrenocortical (HPA) axis and the serotoninergic system in a transgenic model of vulnerability to affective disorders. GR-i mice showed a decreas...

Claims have been made recently that glyphosate-resistant (GR) crops sometimes have mineral deficiencies and increased plant disease. This review evaluates the literature that is germane to these claims. Our conclusions are: (1) although there is conflicting literature on the effects of glyphosate on mineral nutrition on GR crops, most of the literature indicates that mineral nutrition in GR cro...

Glucocorticoids are widely used to suppress inflammation and treat various immune-mediated diseases. Some glucocorticoid receptor (GR)-regulated genes mediate the therapeutic response, whereas others cause debilitating side effects. To discover selective modulators of the GR response, we developed a high-throughput, multiplexed system to monitor regulation of 4 promoters simultaneously. An init...