Pflueger, Axel C., Timothy S. Larson, Siegfried Hagl, and Franklyn G. Knox. Role of nitric oxide in intrarenal hemodynamics in experimental diabetes mellitus in rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R725–R733, 1999.—The role of nitric oxide (NO) in the regulation of the intrarenal microcirculation in streptozotocin (STZ)-induced diabetes mellitus in rats is not c...

Schwartz, Gary J., Andrew Whitney, Chris Skoglund, Thomas W. Castonguay and Timothy H. Moran. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-Areceptors. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1144– R1151, 1999.—Adult Otsuka Long-Evans Tokushima fatty (OLETF) rats lack functional cholecystokinin A (CCK-A) receptors, are dia...

Korthuis, Ronald J., Dean C. Gute, Frank Blecha, and Chris R. Ross. PR-39, a proline/arginine-rich antimicrobial peptide, prevents postischemic microvascular dysfunction. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H1007– H1013, 1999.—We and others have previously demonstrated that intestinal ischemia-reperfusion (I/R) is associated with a large increase in oxidant production that contribute...

Rinaman, Linda. Interoceptive stress activates glucagonlike peptide-1 neurons that project to the hypothalamus. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R582–R590, 1999.—This study tested the hypothesis that systemic stressors in rats activate glucagon-like peptide-1 (GLP-1)-immunoreactive neurons in the caudal brain stem, including those that project to the paraventricul...

Tonkonogi, M., and K. Sahlin. Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria. Am. J. Physiol. 277 (Cell Physiol. 46): C288–C293, 1999.—Oxidative phosphorylation of isolated rat skeletal muscle mitochondria after exposure to lactic acidosis in either phosphorylating or nonphosphorylating states has been evaluated. Mitochondrial respiration ...

Manfridi, Alfredo, Dario Brambilla, and Mauro Mancia. Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1488–R1492, 1999.—The nucleus basalis of Meynert (NBM), a heterogeneous area in the basal forebrain involved in the modulation of sleep and wakefulness, is rich in glutamate receptors, a...

Prinz, Christian, Robert Zanner, Markus Gerhard, Sabine Mahr, Nina Neumayer, Barbara Höhne-Zell, and Manfred Gratzl. The mechanism of histamine secretion from gastric enterochromaffin-like cells. Am. J. Physiol. 277 (Cell Physiol. 46): C845–C855, 1999.— Enterochromaffin-like (ECL) cells play a pivotal role in the peripheral regulation of gastric acid secretion as they respond to the functionall...

Ahrén, Bo, and Peter J. Havel. Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells). Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R959–R966, 1999.—The effect of leptin on insulin secretion is controversial due to conflicting results in the literature. In the present study, we incubated insulinproducing rat insulinoma INS-1 cells...

Dodd, J. S., J. A. Raleigh, and T. S. Gross. Osteocyte hypoxia: a novel mechanotransduction pathway. Am. J. Physiol. 277 (Cell Physiol. 46): C598–C602, 1999.—Bone is a unique tissue in which to examine mechanotransduction due to its essential role in weight bearing. Within bone, the osteocyte is an ideal cellular mechanotransducer candidate. Because osteocytes reside distant from the blood supp...

RAGAVENDRA R. BALIGA,1 DAVID R. PIMENTAL,1 YOU-YANG ZHAO,2 WILLIAM W. SIMMONS,1 MARK A. MARCHIONNI,3 DOUGLAS B. SAWYER,1 AND RALPH A. KELLY1 1Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School, Boston 02115; 3Cambridge Neurosciences, Cambridge, Massachusetts 02139; and 2Department of Medicine, University of California at San Diego School of Medicine, La Jolla, Cali...